ArticleThe Journal of biological chemistry2013
The developing chicken yolk sac acquires nutrient transport competence by an orchestrated differentiation process of its endodermal epithelial cells.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Single-cell transcriptomic insights into lipoprotein transport in yolk sac membrane endodermal epithelial cells of chicken embryos.Poultry science · 2026Article
- Effects of Broiler Breeder Age on Egg Quality, Incubation Performance, and Early Progeny Physiological and Muscle Fiber Development.Journal of animal physiology and animal nutrition · 2026Article
- Development and functions of the area opaca of the chick embryo.Developmental biology · 2025Review
- Article
- Renal Endocytic Regulation of Vitamin D Metabolism during Maturation and Aging in Laying Hens.Animals : an open access journal from MDPI · 2024Article
- Metabolomics analysis of the yolk of Zhijin white goose during the embryogenesis based on LC-MS/MS.PloS one · 2024Article
- Reserves of Calcium, Copper, Iron, Potassium, Magnesium, Manganese, Sodium, Phosphorus, Strontium and Zinc in Goose Egg Yolk during Embryo Development.Animals : an open access journal from MDPI · 2023Article
- Gluconeogenesis in the Yolk Sac Membrane: Enzyme Activity, Gene Expression, and Metabolites During Layer Chicken Development.The journal of poultry science · 2023Article
- The HDL particle composition determines its antitumor activity in pancreatic cancer.Life science alliance · 2022Article
- Developmental Change of Yolk Microbiota and Its Role on Early Colonization of Intestinal Microbiota in Chicken Embryo.Animals : an open access journal from MDPI · 2021Article
- The role of dynamin in absorbing lipids into endodermal epithelial cells of yolk sac membranes during embryonic development in Japanese quail.Poultry science · 2021Article
- Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost (Xenotoca eiseni).The Journal of experimental biology · 2021Article
- Centennial Review: The chicken yolk sac is a multifunctional organ.Poultry science · 2021Review
- Article
- Chicken embryo development: metabolic and morphological basis for in ovo feeding technology.Poultry science · 2020Review
- Incubation temperature affects yolk utilization through changes in expression of yolk sac tissue functional genes.Poultry science · 2020Article
- 3D Cell Culture of Human Salivary Glands Using Nature-Inspired Functional Biomaterials: The Egg Yolk Plasma and Egg White.Materials (Basel, Switzerland) · 2020Article
- The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics.Investigative ophthalmology & visual science · 2020Article
- A differentiation program induced by bone morphogenetic proteins 4 and 7 in endodermal epithelial cells provides the molecular basis for efficient nutrient transport by the chicken yolk sac.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Enriching ISA brown and Shaver white breeder diets with sources of n-3 polyunsaturated fatty acids increased embryonic utilization of docosahexaenoic acid.Poultry science · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrating endodermal epithelial cell (EEC) layer in the area vitellina. Ultimately, these cells form the vascularized YS that functions in nutrient transfer to the embryo. How and when EECs, with their apical aspect directly contacting the oocytic yolk, acquire the ability to take up yolk macromolecules during the vitellina-to-vasculosa transition has not been investigated. In addressing these questions, we found that with progressive vascularization, the expression level in EECs of the nutrient receptor triad, LRP2-cubilin-amnionless, changes significantly. The receptor complex, competent for uptake of yolk proteins, is produced by EECs in the area vasculosa but not in the area vitellina. Yolk components endocytosed by LRP2-cubilin-amnionless, preformed and newly formed lipid droplets, and yolk-derived very low density lipoprotein, shown to be efficiently endocytosed and lysosomally processed by EECs, probably provide substrates for resynthesis and secretion of nutrients, such as lipoproteins. In fact, as directly demonstrated by pulse-chase experiments, EECs in the vascularized, but not in the avascular, region efficiently produce and secrete lipoproteins containing apolipoprotein A-I (apoA-I), apoB, and/or apoA-V. In contrast, perilipin 2, a lipid droplet-stabilizing protein, is produced exclusively by the EECs of the area vitellina. These data suggest a differentiation process that orchestrates the vascularization of the developing YS with the induction of yolk uptake and lipoprotein secretion by EECs to ensure embryo nutrition.
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