ArticleNucleic acids research2013
miRNA target enrichment analysis reveals directly active miRNAs in health and disease.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Representation learning from similarity networks improves the prediction of disease-associated microRNAs.BMC bioinformatics · 2026Article
- MicroRNA-29 acutely regulates memory stability, expression of synaptic genes, and DNA methylation in the mouse adult hippocampus.Cellular and molecular life sciences : CMLS · 2026Article
- bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level.Nucleic acids research · 2026Article
- Inferring single-cell and spatial microRNA activity from transcriptomics data.Communications biology · 2025Article
- Integrating multiple microRNA functional similarity networks for improved disease-microRNA association prediction.Biology methods & protocols · 2025Article
- PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs.Briefings in bioinformatics · 2023Article
- miRNAs as Biomarkers in Diabetes: Moving towards Precision Medicine.International journal of molecular sciences · 2022Review
- Article
- miRNA activity inferred from single cell mRNA expression.Scientific reports · 2021Article
- miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer.PLoS computational biology · 2021Article
- Article
- Robust partitioning of microRNA targets from downstream regulatory changes.Nucleic acids research · 2020Article
- Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta.Toxicology reports · 2020Review
- MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis.BMC bioinformatics · 2019Article
- MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling.Molecular metabolism · 2019Article
- An Enrichment Analysis for Cardiometabolic Traits Suggests Non-Random Assignment of Genes to microRNAs.International journal of molecular sciences · 2018Article
- Genome-wide analysis of fitness data and its application to improve metabolic models.BMC bioinformatics · 2018Article
- SMARTIV: combined sequence and structure de-novo motif discovery for in-vivo RNA binding data.Nucleic acids research · 2018Article
- Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments.Algorithms for molecular biology : AMB · 2018Article
- Random walks on mutual microRNA-target gene interaction network improve the prediction of disease-associated microRNAs.BMC bioinformatics · 2017Article
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4 authors.
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Abstract
microRNAs (miRNAs) are short non-coding regulatory RNA molecules. The activity of a miRNA in a biological process can often be reflected in the expression program that characterizes the outcome of the activity. We introduce a computational approach that infers such activity from high-throughput data using a novel statistical methodology, called minimum-mHG (mmHG), that examines mutual enrichment in two ranked lists. Based on this methodology, we provide a user-friendly web application that supports the statistical assessment of miRNA target enrichment analysis (miTEA) in the top of a ranked list of genes or proteins. Using miTEA, we analyze several target prediction tools by examining performance on public miRNA constitutive expression data. We also apply miTEA to analyze several integrative biology data sets, including a novel matched miRNA/mRNA data set covering nine human tissue types. Our novel findings include proposed direct activity of miR-519 in placenta, a direct activity of the oncogenic miR-15 in different healthy tissue types and a direct activity of the poorly characterized miR-768 in both healthy tissue types and cancer cell lines. The miTEA web application is available at http://cbl-gorilla.cs.technion.ac.il/miTEA/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.