Evidence map›Paper›PMID 23209022›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Lymphatic vessels in health and disease.

Cristina T Kesler, Shan Liao, Lance L Munn, Timothy P Padera

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cristina T KeslerE. L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Shan Liao
Lance L Munn
Timothy P Padera
Harvard University · USMassachusetts General Hospital · US

Funding

Vascular Normalization: Rolse of Perivascular CellsP01CA080124 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2000 to 2016
$35.0M
Training Program in Pathophysiology of Solid TumorsT32CA073479 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 1998 to 2012
$3.0M
Characterizing lymphatic micrometastases: prognostic and therapeutic implicationsDP2OD008780 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2011 to 2011
$2.6M
Encouraging anastomosis of engrafted vascular networksR01HL106584 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2012 to 2015
$1.3M
Flow-based remodeling and function of tumor vasculatureR01CA149285 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2010 to 2013
$1.3M
Lymphatic RadiobiologyR00CA137167 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2011 to 2013
$699k
Characterization of lymphatic contraction during infectionR21AI097745 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2012 to 2013
$480k
The role of lymphatic contraction in inflammation and cancer metastasisK99HL111343 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LIAO, SHAN · 2012 to 2013
$260k
NCI NIH HHS P01 CA080124NCI NIH HHS R00 CA137167NCI NIH HHS R00CA137167NCI NIH HHS R01 CA149285NCI NIH HHS R01CA149285NCI NIH HHS T32 CA073479NCI NIH HHS T32CA073479NHLBI NIH HHS K99 HL111343NHLBI NIH HHS R01 HL106584NHLBI NIH HHS R01HL106584NIAID NIH HHS R21 AI097745NIAID NIH HHS R21AI097745NIH HHS DP2 OD008780NIH HHS DP2OD008780
6 · The paper itself

Abstract

The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling occur primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology.

Indexed as

Models, BiologicalAnimalsHumansLymphLymphatic DiseasesLymphatic Vessels

Identifiers

PMID23209022
PMCPMC3527689
OpenAlexW2014521014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.