Evidence map›Paper›PMID 23208995›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2013

Zebrafish: an in vivo model for nano EHS studies.

Sijie Lin, Yan Zhao, André E Nel, Shuo Lin

Abstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. TiOInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Biology · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Marine drugs · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sijie LinCenter for Environmental Implications of Nanotechnology, 570 Westwood Plaza, Bldg114, Rm 6511, Los Angeles, CA 90095, USA.
Yan Zhao
André E Nel
Shuo Lin

Funding

Scientific Core: Acquisition, Synthesis, and Characterization of NanomaterialsU19ES019528 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2010 to 2014
$5.5M
Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the LungR01ES016746 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2008 to 2017
$3.4M
GENETIC ANALYSIS OF HEMATOPOIETIC DEVELOPMENTR01DK054508 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIN, SHUO · 1998 to 2012
$3.4M
High-throughput gene disruption in zebrafish using retroviral integrationR01DK084349 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIN, SHUO · 2009 to 2012
$1.4M
NIDDK NIH HHS 5R01DK054508-15NIDDK NIH HHS 5R01DK084349-03NIDDK NIH HHS R01 DK054508NIDDK NIH HHS R01 DK084349NIEHS NIH HHS R01 ES016746NIEHS NIH HHS U19 ES019528
6 · The paper itself

Abstract

To assure a responsible and sustainable growth of nanotechnology, the environmental health and safety (EHS) aspect of engineered nanomaterials and nano-related products needs to be addressed at a rate commensurate with the expansion of nanotechnology. Zebrafish has been demonstrated as a correlative in vivo vertebrate model for such task, and the current advances of using zebrafish for nano EHS studies are summarized here. In addition to morphological and histopathological observations, the accessibility of gene manipulation would greatly empower such a model for detailed mechanistic studies of any nanoparticles of interest. The potential for establishing high-throughput screening platforms to facilitate the nano EHS studies is highlighted, and a discussion is presented on how toxicogenomics approaches represent a future direction to guide the identification of toxicity pathways.

Indexed as

Environmental HealthModels, BiologicalNanotechnologyAnimalsEnvironmental MonitoringZebrafish

Identifiers

PMID23208995
PMCPMC4070293

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.