Evidence map›Paper›PMID 23208876›Full record

Trial reportThe American journal of tropical medicine and hygiene2013

A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger.

Abdou Amza, Boubacar Kadri, Baido Nassirou, Nicole E Stoller, Sun N Yu, Zhaoxia Zhou, Sheila K West, David C W Mabey, Robin L Bailey, Jeremy D Keenan and 3 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Abdou Amza
Boubacar Kadri
Baido Nassirou
Nicole E Stoller
Sun N Yu
Zhaoxia Zhou
Sheila K West
David C W Mabey
Robin L Bailey
Jeremy D Keenan
Travis C Porco
Thomas M Lietman
Bruce D Gaynor
University of California, San Francisco · USAbdou Moumouni University · NELondon School of Hygiene & Tropical Medicine · GB

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Primary and Secondary Effects of Mass Antibiotic Distributions for TrachomaK23EY019881 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAYNOR, BRUCE D. · 2010 to 2014
$1.1M
NCRR NIH HHS KL2 RR024130NEI NIH HHS K23 EY019881PHS HHS K23 EYO19881-01
6 · The paper itself

Abstract

Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6-60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46-1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists.

Indexed as

Anti-Bacterial AgentsAzithromycinCluster AnalysisGrowthHumansNigerNutritional StatusAnti-Bacterial AgentsAzithromycin

Identifiers

PMID23208876
PMCPMC3541724
OpenAlexW2117086741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.