ArticleInfection and immunity2013
Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidity.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Shared challenges to the control of complex intracellular neglected pathogens.Frontiers in public health · 2024Review
- BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis.Frontiers in immunology · 2021Article
- Interactions Between PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes.Scientific reports · 2020Observational
- Human Melioidosis.Clinical microbiology reviews · 2020Review
- The Impact of Age and Sex on Mouse Models of Melioidosis.Pathogens (Basel, Switzerland) · 2020Article
- The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System.Frontiers in immunology · 2020Review
- Diabetes alters immune response patterns to acute melioidosis in humans.European journal of immunology · 2019Article
- Host gene expression analysis in Sri Lankan melioidosis patients.PLoS neglected tropical diseases · 2017Article
- Considerations for Infectious Disease Research Studies Using Animals.Comparative medicine · 2017Review
- Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei.Scientific reports · 2017Article
- Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.Microbes and infection · 2016Article
- The Impact of Prior Flavivirus Infections on the Development of Type 2 Diabetes Among the Indigenous Australians.The American journal of tropical medicine and hygiene · 2016Article
- Consensus on the development of vaccines against naturally acquired melioidosis.Emerging infectious diseases · 2015Article
- New insights from the 7th World Melioidosis Congress 2013.Emerging infectious diseases · 2014Article
- No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice.PloS one · 2014Article
- Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection.Scientific reports · 2013Article
- Article
- Glyburide reduces bacterial dissemination in a mouse model of melioidosis.PLoS neglected tropical diseases · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial infections are a common and serious complication of type 2 diabetes (T2D). The prevalence of melioidosis, an emerging tropical infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is increased in people with T2D. This is the first study to compare murine models of T2D and melioidosis. Susceptibility and disease progression following infection with B. pseudomallei were compared in our diet-induced polygenic mouse model and a leptin receptor-deficient monogenic model of T2D. The metabolic profile of mice with diet-induced diabetes, including body weight, blood glucose, cholesterol, triglycerides, insulin resistance, and baseline levels of inflammation, closely resembled that of clinical T2D. Following subcutaneous infection with B. pseudomallei, bacterial loads at 24 and 72 h postinfection in the blood, spleen, liver, lungs, and subcutaneous adipose tissue (SAT) at the site of infection were compared in parallel with the expression of inflammatory cytokines and tissue histology. As early as 24 h postinfection, the expression of inflammatory (interleukin-1β [IL-1β], tumor necrosis factor alpha [TNF-α], and IL-6) and T(H)1 (IL-12 and gamma interferon [IFN-γ]) cytokines was impaired in diabetic mice compared to nondiabetic littermates. Early differences in cytokine expression were associated with excessive infiltration of polymorphonuclear neutrophils (PMN) in diabetic mice compared to nondiabetic littermates. This was accompanied by bacteremia, hematogenous dissemination of bacteria to the lungs, and uncontrolled bacterial growth in the spleens of diabetic mice by 72 h postinfection. The findings from our novel model of T2D and melioidosis comorbidity support the role of impaired early immune pathways in the increased susceptibility of individuals with T2D to bacterial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.