ArticleMolecules (Basel, Switzerland)2012
Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia.BMC pharmacology & toxicology · 2023Article
- The Complete Chloroplast Genome ofGenes · 2022Article
- Article
- Preliminary Study of Gastroprotective Effect ofBioMed research international · 2022Article
- Metabolites Profiling, In Vitro, In Vivo, Computational Pharmacokinetics and Biological Predictions ofPlants (Basel, Switzerland) · 2021Article
- Review
- Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya.Chinese medicine · 2020Article
- Chemo Suppressive and Curative Potential ofJournal of experimental pharmacology · 2020Article
- Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates fromEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Article
- Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats.BMC complementary and alternative medicine · 2018Article
- Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against Leishmania amazonensis.BioMed research international · 2015Article
- In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria, leishmaniasis and human African trypanosomiasis continue to be major public health problems in need of new and more effective drugs. The aim of this study was to evaluate in vitro antiprotozoal activity of twenty endemic medicinal plants collected from the island of Soqotra in the Indian Ocean. The plant materials were extracted with methanol and tested for antiplasmodial activity against erythrocytic schizonts of Plasmodium falciparum, for antileishmanial activity against intracellular amastigotes of Leishmania infantum and for antitrypanosomal activity against intracellular amastigotes of Trypanosoma cruzi and free trypomastigotes of T. brucei. To assess selectivity, cytotoxicity was determined against MRC-5 fibroblasts. Selective activity was obtained for Punica protopunica against Plasmodium (IC₅₀ 2.2 µg/mL) while Eureiandra balfourii and Hypoestes pubescens displayed activity against the three kinetoplastid parasites (IC₅₀ < 10 µg/mL). Acridocarpus socotranus showed activity against T. brucei and T. cruzi (IC₅₀ 3.5 and 8.4 µg/mL). Ballochia atrovirgata, Dendrosicycos socotrana, Dracaena cinnabari and Euphorbia socotrana displayed non-specific inhibition of the parasites related to high cytotoxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.