ArticleMolecules (Basel, Switzerland)2012
Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) callus and cell suspension culture.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Quality evaluation ofFrontiers in plant science · 2026Article
- Deoxyshikonin: a promising lead drug grass against drug resistance or sensitivity toAntimicrobial agents and chemotherapy · 2024Article
- Euchronin A-F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro.Journal of natural medicines · 2024Article
- Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022.Chinese herbal medicines · 2022Review
- Component Composition and Biological Activity of Various Extracts ofInternational journal of biomaterials · 2022Article
- Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives.International journal of molecular sciences · 2021Article
- Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review.Pharmaceutical biology · 2020Review
- Screening of Bioactive Metabolites and Biological Activities of Calli, Shoots, and Seedlings ofPlants (Basel, Switzerland) · 2020Article
- Dissection for Floral Micromorphology and Plastid Genome of Valuable Medicinal Borages Arnebia and Lithospermum (Boraginaceae).Frontiers in plant science · 2020Article
- In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5Drug design, development and therapy · 2019Article
- Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells.Molecules (Basel, Switzerland) · 2018Article
- Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis.Scientific reports · 2018Article
- Shikonin Production by Callus Culture ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Biological properties of mud extracts derived from various spa resorts.Environmental geochemistry and health · 2017Article
- Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes.Molecules (Basel, Switzerland) · 2016Article
- Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Oncotarget · 2015Article
- The Mechanism Underlying the Antibacterial Activity of Shikonin against Methicillin-Resistant Staphylococcus aureus.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Comparing the Healing Effects of Arnebia euchroma Ointment With Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial.Iranian Red Crescent medical journal · 2014Article
- Two polycyclic geranylhydroquinone-derived metabolites from roots of Arnebia hispidissima (Lehm.) DC.Molecules (Basel, Switzerland) · 2014Article
- Liquid perfluorodecalin application for in situ extraction and enhanced naphthoquinones production in Arnebia euchroma cell suspension cultures.Applied biochemistry and biotechnology · 2014Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The phytochemical investigation of the n-hexane extract from callus and cell suspension culture of Arnebia euchroma (Royle) Jonst. resulted in the isolation of nine isohexenylnaphthazarins: deoxyalkannin (1), alkannin (2), acetylalkannin (3), isobutyrylalkannin (4), β-hydroxyisovalerylalkannin (5), 2''-(S)-α-methylbutyrylalkannin (6), propionylalkannin (7), teracrylalkannin (8) and acetylshikonin (9). Their structures were determined by MS and NMR spectroscopy. Pigments 2–8 are isolated for the first time from Arnebia in vitro cultures, 4 and 7 are reported in the present work as novel metabolites within the Arnebia genus, while 9 is a known constituent of both natural roots and in vitro cultures of A. euchroma. Moreover, methyl jasmonate and 1-monoglyceryl olate, palmitate and stearate are reported for the first time within the Boraginaceae family. The antimicrobial and cytotoxic activities of all isolated pigment compounds were tested, revealing a very interesting profile.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.