Evidence map›Paper›PMID 23208422›Full record

ArticleCell research2013

Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.

Yiwu Yan, Zhen Zou, Yang Sun, Xiao Li, Kai-Feng Xu, Yuquan Wei, Ningyi Jin, Chengyu Jiang

4 registry-linked trialsOpen access · bronzeAbstract readLetter
In one paragraph

Article in Cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 180 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04359095 phase2 / phase3completednot on this mapstarted 2020, after this paper: background citation

Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled Trial

TypeinterventionalSponsorUniversidad Nacional de ColombiaRan2020 to 2021Enrolled650ConditionsCOVID-19ArmsEmtricitabine/tenofovir, Colchicine Pill, Rosuvastatin, Standard treatment
NCT04394416 phase3terminatednot on this mapstarted 2020, after this paper: background citation

Randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults With COVID-19

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2020 to 2025Enrolled21ConditionsCOVID-19ArmsImatinib, Placebo oral tablet
NCT04400019 phase2 / phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

Prevention of COVID19 Infection by the Administration of Hydroxychloroquine to Institutionalized Older People and Nursing Home Staff. Controlled Clinical Trial, Randomized Triple Blind by Clusters (PREVICHARM Study)

TypeinterventionalSponsorUniversity of MalagaRan2020 to 2021Enrolled1,930ConditionsSars-CoV2, Coronavirus Infection, Prevention & Control, Nursing HomeArmsHydroxychloroquine Only Product in Oral Dose Form
NCT04627467 phase2completednot on this mapstarted 2020, after this paper: background citation

Prophylaxis With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19)

TypeinterventionalSponsorFundacion Clinica Valle del LiliRan2020 to 2021Enrolled3,217ConditionsCovid19ArmsChloroquine
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 4 syntheses or guidelines pooled it, 352 citations in OpenAlex.

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  14. Autophagy and SARS-CoV-2-Old Players in New Games.International journal of molecular sciences · 2023
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yiwu Yan
Zhen Zou
Yang Sun
Xiao Li
Kai-Feng Xu
Yuquan Wei
Ningyi Jin
Chengyu Jiang
Chinese Academy of Medical Sciences & Peking Union Medical College · CNAcademy of Military Medical Sciences · CNSichuan University · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntimalarialsBirdsCell Line, TumorCell SurvivalChloroquineDisease Models, AnimalHumansInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsAntimalarialsChloroquine

Identifiers

PMID23208422
PMCPMC3567830
OpenAlexW2074095102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.