Trial reportAnnals of internal medicine2012
Efficacy of a clinical decision-support system in an HIV practice: a randomized trial.
Trial report in Annals of internal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing HIV Disease-Specific Provider Alerts: A Randomized Controlled Informatics Trial Comparing Electronic Health Record (EHR) vs. Non-EHR Provider Alerts
Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors (AH-HA)
Who cites it
26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care.The Cochrane database of systematic reviews · 2025Pooled it
- Conceptualizing clinical decision support as complex interventions: a meta-analysis of comparative effectiveness trials.Journal of the American Medical Informatics Association : JAMIA · 2022Pooled it
- Health Information Technology Continues to Show Positive Effect on Medical Outcomes: Systematic Review.Journal of medical Internet research · 2018Pooled it
- Challenges in the Evaluation of Interventions to Improve Engagement Along the HIV Care Continuum in the United States: A Systematic Review.AIDS and behavior · 2017Pooled it
- Identifying Best Practices for Increasing Linkage to, Retention, and Re-engagement in HIV Medical Care: Findings from a Systematic Review, 1996-2014.AIDS and behavior · 2016Pooled it
- Effectiveness of computerized decision support systems linked to electronic health records: a systematic review and meta-analysis.American journal of public health · 2014Pooled it
- The effects of on-screen, point of care computer reminders on processes and outcomes of care.The Cochrane database of systematic reviews · 2009Pooled it
- HIV retention in care: results and lessons learned from the Positive Pathways Implementation Trial.BMC primary care · 2022Trial
- Advancing Human-Centered AI in Clinical Decision Support: Sociocognitive Human-in-the-Loop Study in HIV Care.Journal of medical Internet research · 2026Article
- What Tools Do We Have to End the US HIV Epidemic? A Review of Structural, Biomedical and Implementation Interventions and Their Potential Population Impact.Journal of the International AIDS Society · 2026Review
- High effectiveness of the digitalization of the GESIDA clinical guideline for HIV patient management.BMC health services research · 2025Article
- Prioritization of Evidence-Based and Evidence-Informed Interventions for Retention in Medical Care for Persons with HIV.AIDS and behavior · 2023Review
- An EMR-Based Alert with Brief Provider-Led ART Adherence Counseling: Promising Results of the InfoPlus Adherence Pilot Study Among Haitian Adults with HIV Initiating ART.AIDS and behavior · 2020Article
- Ending the HIV Epidemic Among Persons Who Inject Drugs: A Cost-Effectiveness Analysis in Six US Cities.The Journal of infectious diseases · 2020Article
- Effects of Computerized Decision Support Systems on Practitioner Performance and Patient Outcomes: Systematic Review.JMIR medical informatics · 2020Review
- [Improved patient safety through a clinical decision support system in laboratory medicine].Der Internist · 2020Review
- Oncologists' Perceptions of a Digital Tool to Improve Cancer Survivors' Cardiovascular Health.ACI open · 2019Article
- Improving HIV Care Engagement in the South from the Patient and Provider Perspective: The Role of Stigma, Social Support, and Shared Decision-Making.AIDS patient care and STDs · 2018Article
- Article
- A Rapid Review of eHealth Interventions Addressing the Continuum of HIV Care (2007-2017).AIDS and behavior · 2018Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundData to support improved patient outcomes from clinical decision-support systems (CDSSs) are lacking in HIV care.
objectiveTo test the efficacy of a CDSS in improving HIV outcomes in an outpatient clinic.
designRandomized, controlled trial. (ClinicalTrials.gov registration number: NCT00678600)
settingMassachusetts General Hospital HIV Clinic.
participantsHIV care providers and their patients.
interventionComputer alerts were generated for virologic failure (HIV RNA level >400 copies/mL after a previous HIV RNA level ≤400 copies/mL), evidence of suboptimal follow-up, and 11 abnormal laboratory test results. Providers received interactive computer alerts, facilitating appointment rescheduling and repeated laboratory testing, for half of their patients and static alerts for the other half. MEASUREMENTS: The primary end point was change in CD4 cell count. Other end points included time to clinical event, 6-month suboptimal follow-up, and severe laboratory toxicity.
resultsThirty-three HIV care providers followed 1011 patients with HIV. In the intervention group, the mean increase in CD4 cell count was greater (0.0053 vs. 0.0032 × 109 cells/L per month; difference, 0.0021 × 109 cells/L per month [95% CI, 0.0001 to 0.004]; P = 0.040) and the rate of 6-month suboptimal follow-up was lower (20.6 vs. 30.1 events per 100 patient-years; P = 0.022) than those in the control group. Median time to next scheduled appointment was shorter in the intervention group than in the control group after a suboptimal follow-up alert (1.71 vs. 3.48 months; P < 0.001) and after a toxicity alert (2.79 vs. >6 months; P = 0.072). More than 90% of providers supported adopting the CDSS as part of standard care. LIMITATION: This was a 1-year informatics study conducted at a single hospital subspecialty clinic.
conclusionA CDSS using interactive provider alerts improved CD4 cell counts and clinic follow-up for patients with HIV. Wider implementation of such systems can provide important clinical benefits. PRIMARY FUNDING SOURCE: National Institute of Allergy and Infectious Diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.