ArticleThe Journal of physiology2013
Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex).
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Interdependence of cellular and network properties in respiratory rhythm generation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interdependence of cellular and network properties in respiratory rhythmogenesis.bioRxiv : the preprint server for biology · 2023Article
- T cell infiltration into the brain triggers pulmonary dysfunction in murine Cryptococcus-associated IRIS.Nature communications · 2023Article
- Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 2: TRPM4 in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- CAMK2-Dependent Signaling in Neurons Is Essential for Survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Increased TRPM4 Activity in Cerebral Artery Myocytes Contributes to Cerebral Blood Flow Reduction After Subarachnoid Hemorrhage in Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.PLoS biology · 2019Article
- CA1 Neurons Acquire Rett Syndrome Phenotype After Brief Activation of Glutamatergic Receptors: Specific Role of mGluR1/5.Frontiers in cellular neuroscience · 2018Article
- Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.Frontiers in cellular neuroscience · 2018Article
- Functional Interactions between Mammalian Respiratory Rhythmogenic and Premotor Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Acute intermittent optogenetic stimulation of nucleus tractus solitarius neurons induces sympathetic long-term facilitation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.The Journal of physiology · 2014Article
- Modeling CaMKII in cardiac physiology: from molecule to tissue.Frontiers in pharmacology · 2014Review
- TRPM4 channels in smooth muscle function.Pflugers Archiv : European journal of physiology · 2013Review
- I think I(CAN): modulation of TRPM4 channels may contribute not only to the emergence of rhythm, but robust output and metabolic sensitivity of the preBötzinger Complex inspiratory network.The Journal of physiology · 2013Article
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Abstract
Emergence of persistent activity in networks can be controlled by intracellular signalling pathways but the mechanisms involved and their role are not yet fully explored. Using calcium imaging and patch-clamp we examined the rhythmic activity in the preBötzinger complex (preBötC) in the lower brainstem that generates the respiratory motor output. In functionally intact acute slices brief hypoxia, electrical stimulation and activation of AMPA receptors transiently depressed bursting activity which then recovered with augmentation. The effects were abrogated after chelation of intracellular calcium, blockade of L-type calcium channels and inhibition of calmodulin (CaM) and CaM kinase (CaMKII). Rhythmic calcium transients and synaptic drive currents in preBötC neurons in the organotypic slices showed similar CaM- and CaMKII-dependent responses. The stimuli increased the amplitude of spontaneous and miniature excitatory synaptic currents indicating postsynaptic changes at glutamatergic synapses. In the acute and organotypic slices, CaM stimulated and ADP inhibited calcium-dependent TRPM4 channels and CaMKII augmented synaptic drive currents. Experimental data and simulations show the role of ADP and CaMKII in the control of bursting activity and its relation to intracellular signalling. I propose that CaMKII-mediated facilitation of glutamatergic transmission strengthens emergent synchronous activity within preBötC that is then maintained by periodic surges of calcium during the bursts. This may find implications in restoration and consolidation of autonomous activity in the respiratory disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.