ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
The expression of Toll-like receptors in murine Müller cells, the glial cells in retina.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluating the Evidence for Neuroprotective and Axonal Regenerative Activities of Different Inflammatory Cell Types After Optic Nerve Injury.Molecular neurobiology · 2025Review
- Identification of immune-associated genes with altered expression in the spleen of mice enriched with probiotic Lactobacillus species using RNA-seq profiling.Animal bioscience · 2025Article
- Induction, amplification, and propagation of diabetic retinopathy-associated inflammatory cytokines between human retinal microvascular endothelial and Müller cells and in the mouse retina.Cellular signalling · 2024Article
- TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins.International journal of molecular sciences · 2024Article
- The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.Journal of neuroinflammation · 2024Review
- Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion.Frontiers in cell and developmental biology · 2024Article
- Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma.International journal of molecular sciences · 2023Review
- Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice.Frontiers in cellular and infection microbiology · 2022Article
- MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4.Experimental & molecular medicine · 2021Article
- Article
- The Absence of Toll-Like Receptor 4 Mildly Affects the Structure and Function in the Adult Mouse Retina.Frontiers in cellular neuroscience · 2019Article
- Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons.Journal of neuroimmunology · 2018Article
- Dexamethasone protects retinal ganglion cells but not Müller glia against hyperglycemia in vitro.PloS one · 2018Article
- Toll-like receptor 4 regulates insulin signal transduction in retinal Müller cells.Growth factors (Chur, Switzerland) · 2017Article
- Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and -independent signaling.PloS one · 2017Article
- β-Adrenergic receptor agonist, compound 49b, inhibits TLR4 signaling pathway in diabetic retina.Immunology and cell biology · 2016Article
- The role of Toll-like receptors in retinal ischemic diseases.International journal of ophthalmology · 2016Review
- Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells.Journal of neurochemistry · 2015Article
- Role of TLR5 and flagella in bacillus intraocular infection.PloS one · 2014Article
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Müller cells, the principal glial cells of the retina, play an important role in immune responses. Toll-like receptors (TLRs) are members of the pattern recognition receptor family and mediate innate and adaptive immune responses. In this study, we isolated, characterized Müller cells from mouse retina, and analyzed the expression of TLRs in these cells. We found that the mRNA of TLR2, TLR3, TLR4, and TLR5 was highly expressed by Müller cells. PAM3 and LPS, the agonists for TLR2 and TLR4, promoted Müller cells to produce the inflammatory cytokine Interleukine-6 and the chemokine MIP-2/CXCL2. These results suggest that Müller cells may be involved in innate and adaptive responses via TLR signaling in the eye. Our study should facilitate further study of the role of Müller cell in eye diseases and identification of the potential therapeutic targets.
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