ReviewBrain, behavior, and immunity2013
Nervous system regulation of the cancer genome.
Review in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers.Journal of behavioral medicine · 2016Trial
- Curvilinear associations of discrimination attributions with inflammatory and antiviral gene expression.Psychoneuroendocrinology · 2026Article
- Experiences of racial discrimination and adverse gene expression among black individuals in a level 1 trauma center sample.Brain, behavior, and immunity · 2024Article
- Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case-Control Study.Cancers · 2024Article
- The tumor-nerve circuit in breast cancer.Cancer metastasis reviews · 2023Review
- Effect of chronic stress on tumorigenesis and development.Cellular and molecular life sciences : CMLS · 2022Review
- Tone it down: Vagal nerve activity is associated with pro-inflammatory and anti-viral factors in breast cancer - An exploratory study.Comprehensive psychoneuroendocrinology · 2021Article
- Review
- Combinatorial sympathetic and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockades inhibit the murine melanoma growth by targeting infiltrating T cells.Translational cancer research · 2021Article
- Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ.Cancer research and treatment · 2020Article
- Psychosocial issues for adolescent and young adult cancer patients in a global context: A forward-looking approach.Pediatric blood & cancer · 2019Review
- A Pilot Study Using a Multistaged Integrated Analysis of Gene Expression and Methylation to Evaluate Mechanisms for Evening Fatigue in Women Who Received Chemotherapy for Breast Cancer.Biological research for nursing · 2019Article
- Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.Clinical Medicine Insights. Oncology · 2019Article
- Childhood experiences of parenting and cancer risk at older ages: findings from the English Longitudinal Study of Ageing (ELSA).International journal of public health · 2018Article
- Elimination plus Transformation-Chinese and Western Medicine Integration Brings Hope to Protracted War on Cancer.Chinese journal of integrative medicine · 2018Article
- Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.Biological research for nursing · 2016Article
- Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification.Oncotarget · 2016Article
- [New thoughts are needed for the study of liver cancer recurrence and metastasis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016Article
- Long-term Consequences of the Acute Neural-Inflammatory Stress Response in the Cancer Surgical Patient: New Findings and Perspectives.International anesthesiology clinics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Genomics-based analyses have provided deep insight into the basic biology of cancer and are now clarifying the molecular pathways by which psychological and social factors can regulate tumor cell gene expression and genome evolution. This review summarizes basic and clinical research on neural and endocrine regulation of the cancer genome and its interactions with the surrounding tumor microenvironment, including the specific types of genes subject to neural and endocrine regulation, the signal transduction pathways that mediate such effects, and therapeutic approaches that might be deployed to mitigate their impact. Beta-adrenergic signaling from the sympathetic nervous system has been found to up-regulated a diverse array of genes that contribute to tumor progression and metastasis, whereas glucocorticoid-regulated genes can inhibit DNA repair and promote cancer cell survival and resistance to chemotherapy. Relationships between socio-environmental risk factors, neural and endocrine signaling to the tumor microenvironment, and transcriptional responses by cancer cells and surrounding stromal cells are providing new mechanistic insights into the social epidemiology of cancer, new therapeutic approaches for protecting the health of cancer patients, and new molecular biomarkers for assessing the impact of behavioral and pharmacologic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.