ArticleInternational journal for parasitology2013
Three genes involved in the oxidative burst are closely linked in the genome of the snail, Biomphalaria glabrata.
Article in International journal for parasitology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Accelerating snail vector genomics.Infectious diseases of poverty · 2024Article
- Article
- The genome and transcriptome of the snailbioRxiv : the preprint server for biology · 2023Article
- Single-cell RNA-seq profiling of individual Biomphalaria glabrata immune cells with a focus on immunologically relevant transcripts.Immunogenetics · 2022Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
- Transcriptional responses of Biomphalaria pfeifferi and Schistosoma mansoni following exposure to niclosamide, with evidence for a synergistic effect on snails following exposure to both stressors.PLoS neglected tropical diseases · 2019Article
- Comparative study of excretory-secretory proteins released by Schistosoma mansoni-resistant, susceptible and naïve Biomphalaria glabrata.Parasites & vectors · 2019Article
- Effects of the Environment on Developmental Plasticity and Infection Success ofFrontiers in microbiology · 2019Review
- Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection.Tropical medicine and infectious disease · 2018Review
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
- A Targeted Capture Linkage Map Anchors the Genome of the Schistosomiasis Vector Snail,G3 (Bethesda, Md.) · 2017Article
- A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni.PLoS neglected tropical diseases · 2017Article
- Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.Developmental and comparative immunology · 2016Article
- Genome-Wide Scan and Test of Candidate Genes in the Snail Biomphalaria glabrata Reveal New Locus Influencing Resistance to Schistosoma mansoni.PLoS neglected tropical diseases · 2015Article
- The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission.Parasites & vectors · 2014Article
- Resistance of Biomphalaria glabrata 13-16-R1 snails to Schistosoma mansoni PR1 is a function of haemocyte abundance and constitutive levels of specific transcripts in haemocytes.International journal for parasitology · 2014Article
- RNA-Seq reveals infection-induced gene expression changes in the snail intermediate host of the carcinogenic liver fluke, Opisthorchis viverrini.PLoS neglected tropical diseases · 2014Article
- Identification and characterisation of functional expressed sequence tags-derived simple sequence repeat (eSSR) markers for genetic linkage mapping of Schistosoma mansoni juvenile resistance and susceptibility loci in Biomphalaria glabrata.International journal for parasitology · 2013Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
Allelic variation at the Cu-Zn superoxide dismutase (SOD1) locus has been shown to be associated with resistance of the snail, Biomphalaria glabrata, to infection by the trematode parasite, Schistosoma mansoni. SOD1 catalyses the production of hydrogen peroxide, a known cytotoxic component of the oxidative burst used in defence against pathogens. In our laboratory population of B. glabrata, the most resistant allele at SOD1 is over-expressed relative to the other two alleles. Because hydrogen peroxide also causes oxidative stress on host tissues, we hypothesised that over-expression of SOD1 might be compensated by epistatic interactions with other loci involved in oxidation-reduction (redox) pathways. Catalase, peroxiredoxins and glutathione peroxidases all degrade hydrogen peroxide. We tested whether alleles at each of these loci were in linkage disequilibrium with SOD1 in our population, as might be expected given strong epistatic selection. We found that SOD1, catalase (CAT) and a peroxiredoxin locus (PRX4) are in strong linkage disequilibrium in our population. We also found that these loci are tightly linked, within 1-2cM of each other, which explains the high linkage disequilibrium. This result raises the possibility that there is a linked cluster of redox genes, and perhaps other defence-relevant genes, in the B. glabrata genome. Whether epistatic interactions for fitness actually exist among these loci still needs to be tested. However the close physical linkage among SOD1, PRX4 and CAT, and subsequent high disequilibrium, makes such interactions a plausible hypothesis.
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