ArticleBMC complementary and alternative medicine2012
Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo.
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Exploring the therapeutic mechanisms of Gleditsiae Spina acting on pancreatic cancerRSC advances · 2023Article
- Decoding cancer and herbal renaissance.Longhua Chinese medicine · 2022Article
- GT198 Is a Target of Oncology Drugs and Anticancer Herbs.Frontiers in oral health · 2021Article
- Effect ofKorean journal for food science of animal resources · 2017Article
- Natural products against cancer angiogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Effect of Fagonia arabica on thrombin induced release of t-PA and complex of PAI-1 tPA in cultured HUVE cells.Journal of traditional and complementary medicine · 2016Article
- Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors.BMC complementary and alternative medicine · 2016Article
- Gleditsia sinensis Thorn Attenuates the Collagen-Based Migration of PC3 Prostate Cancer Cells through the Suppression of α2β1 Integrin Expression.International journal of molecular sciences · 2016Article
- From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Ethanol extract of Kilkyung-baeksan, a traditional herbal formula, induces G0/G1 cell cycle arrest in human lung cancer cell lines.Integrative medicine research · 2015Article
- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo.Journal of Korean medical science · 2015Article
- The anti-proliferative and anti-angiogenic effect of the methanol extract from brittle star.Reports of biochemistry & molecular biology · 2015Article
- An evaluation of the anti-angiogenic effect of the Korean medicinal formula "Sa-mi-yeon-geon-tang" in vitro and in ovo.BMC complementary and alternative medicine · 2015Article
- Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo.BMC complementary and alternative medicine · 2014Article
- Gleditsia sinensis: transcriptome sequencing, construction, and application of its protein-protein interaction network.BioMed research international · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGleditsia sinensis thorns have been widely used in traditional Korean medicine for the treatment of several diseases, including obesity, thrombosis, and tumor-related diseases. The aim of the study is to determine the antiangiogenic effect of Gleditsia sinensis thorns in vitro and in vivo in a bid to evaluate its potential as an anticancer drug.
methodsEthanol extract of Gleditsia sinensis thorns (EEGS) were prepared and used for in vitro and in vivo assays. In vitro antiangiogenic effect of EEGS was determined in HUVEC primary cells by cell migration and tube formation assays. In vivo antiangiogenic effect of EEGS was determined by measuring vessel formation and vascular endothelial cells migrating into the implanted matrigels in nude mice. The angiogenesis-related proteins of which expression levels were altered by EEGS were identified by proteomic analysis.
resultsEEGS exerted a dose-dependent antiproliferative effect on HUVEC cells without significant cytotoxicity. Angiogenic properties, such as cell migration and tube formation, were significantly inhibited by EEGS in a dose-dependent manner. New vessel formation was also suppressed by EEGS, as determined by the directed in vivo angiogenesis assays in nude mice. EEGS reduced the expression of proangiogenic proteins, endothelin 1 and matrix metallopeptidase 2, in HUVEC cells.
conclusionsOur findings suggest that EEGS can inhibit angiogenesis by down-regulating proangiogenic proteins, and therefore it should be considered as a potential anticancer drug targeting tumor-derived angiogenesis.
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