ArticleProceedings of the National Academy of Sciences of the United States of America1990
Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 58 citations in OpenAlex.
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- The lens actin filament cytoskeleton: Diverse structures for complex functions.Experimental eye research · 2017Review
- Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis.Advances in genetics · 2008Review
- X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression.The Journal of clinical investigation · 2005Article
- Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.Genes & development · 2004Article
- The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis.Molecular medicine (Cambridge, Mass.) · 1998Article
- The role of a single formin isoform in the limb and renal phenotypes of limb deformity.Molecular medicine (Cambridge, Mass.) · 1997Article
- Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.Molecular and cellular biology · 1996Article
- The role of the laboratory mouse in the human genome project.American journal of human genetics · 1996Review
- Biological insights through genomics: mouse to man.The Journal of clinical investigation · 1996Review
- Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The same genomic region is disrupted in two transgene-induced limb deformity alleles.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs.American journal of human genetics · 1991Article
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
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10 authors at 2 institutions in 1 country.
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Abstract
Molecular characterization of mutations in the mouse, particularly those involving agent-induced major structural alterations, is proving to be useful for correlating the structure and expression of individual genes with their function in the whole organism. Here we present the characterization of a radiation-induced mutation that simultaneously generated distinct alleles of both the limb deformity (ld) and agouti (a) loci, two developmentally important regions of chromosome 2 normally separated by 20 centimorgans. Cytogenetic analysis revealed that an interstitial segment of chromosome 17 (17B- 17C; or, possibly, 17A2-17B) had been translocated into the distal end of chromosome 2, resulting in a smaller-than-normal chromosome 17 (designated 17del) and a larger form of chromosome 2 (designated 2(17). Additionally, a large interstitial segment of the 2(17) chromosome, immediately adjacent and proximal to the insertion site, did not match bands 2E4-2H1 at corresponding positions on a normal chromosome 2. Molecular analysis detected a DNA rearrangement in which a portion of the ld locus was joined to sequences normally tightly linked to the a locus. This result, along with the genetic and cytogenetic data, suggests that the alleles of ld and a in this radiation-induced mutation, designated ldIn2 and ajIn2, were associated with DNA breaks caused by an inversion of an interstitial segment in the 2(17) chromosome.
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