ArticleJournal of clinical hypertension (Greenwich, Conn.)2012
Severity of peripheral arterial disease is associated with aortic pressure augmentation and subendocardial viability ratio.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Risk Stratification of Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm Using Aortic Augmentation Index.PloS one · 2015Trial
- Subendocardial Viability Ratio Is Associated With Target Organ Damage and Hints at a Potential Independent Predictor of Cardiovascular Mortality in Older Adults: A Prospective Cohort Study.Journal of the American Heart Association · 2026Observational
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology · 2024Article
- Research Progress and Clinical Value of Subendocardial Viability Ratio.Journal of the American Heart Association · 2024Review
- A cross-sectional study in type 2 diabetes patients reveals that elevated pulse wave velocity predicts asymptomatic peripheral arterial disease associated with age and diabetes duration.International journal of cardiology. Heart & vasculature · 2023Article
- Aortic blood pressure and pulse wave indices responses to exercise in peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease.BMC cardiovascular disorders · 2021Article
- Endovascular Revascularization Improves the Central Hemodynamics and Augmentation Index in Patients with Peripheral Artery Disease.Internal medicine (Tokyo, Japan) · 2020Article
- Applications of arterial stiffness markers in peripheral arterial disease.Jornal vascular brasileiro · 2019Review
- Arterial stiffness and subendocardial viability ratio in patients with peripheral arterial disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Increase in the Arterial Velocity Pulse Index of Patients with Peripheral Artery Disease.Pulse (Basel, Switzerland) · 2018Article
- Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.Physiological genomics · 2018Article
- Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry.Journal of vascular surgery · 2017Article
- Peripheral vascular disease is associated with increased pulse wave velocity and augmentation index: clinical implications.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Aortic augmentation index in patients with peripheral arterial disease.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- A new tonometric device for radial augmentation index and subendocardial viability ratio: potential use in health screening.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Impaired subendocardial perfusion in patients with metabolic syndrome.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral arterial disease (PAD) is associated with increased cardiovascular mortality that correlates with peripheral perfusion impairment as assessed by the ankle-brachial arterial pressure index (ABI). Furthermore, PAD is associated with arterial stiffness and elevated aortic augmentation index (AIx). The purpose of this study was to investigate whether ABI impairment correlates with AIx and subendocardial viability ratio (SEVR), a measure of cardiac perfusion during diastole. AIx and SEVR were assessed by radial applanation tonometry in 65 patients with stable PAD (Rutherford stage I-III) at a tertiary referral center. AIx corrected for heart rate and SEVR were tested in a multivariate linear and logistic regression model to determine the association with ABI. Mean ABI was 0.8±0.2, AIx 31%±7%, and SEVR 141%±26%. Multiple linear regression with AIx as a dependent variable revealed that AIx was significantly negatively associated with ABI (β=-11.5; 95% confidence interval [CI], -18.6 to -4.5; P=.002). Other variables that were associated with AIx were diastolic blood pressure (β=0.2; 95% CI, 0.1-0.4; P<.001), height (β=-46.2; 95% CI, -62.9 to -29.4; P<.001), body mass index (β=-0.4; 95% CI, -0.8 to -0.1; P=.023), and smoking (β=3.6; 95% CI, 0.6-6.6; P=.019). Multiple regression with SEVR as a dependent variable showed a significant correlation with ABI (β=33.2; 95% CI, 2.3-64.1; P=.036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.