ArticleExperimental and clinical psychopharmacology2013
Age of alcohol and cannabis use onset mediates the association of transmissible risk in childhood and development of alcohol and cannabis disorders: evidence for common liability.
Article in Experimental and clinical psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Indicators of Intergenerational Transmission of Cannabis Use Among US Young Adults.Substance use & addiction journal · 2025Article
- The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry.Addiction (Abingdon, England) · 2021Article
- Intergenerational marijuana use: A life course examination of the relationship between parental trajectories of marijuana use and the onset of marijuana use by offspring.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- School-based interventions for preventing substance use in indigenous children ages 7-13: a scoping review protocol.BMJ open · 2020Article
- Adolescent Behavioral Characteristics Mediate Familial Effects on Alcohol Use and Problems in College-Bound Students.Substance abuse : research and treatment · 2020Article
- Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.Brain imaging and behavior · 2018Article
- Longitudinal Studies on the Etiology of Cannabis Use Disorder: A Review.Current addiction reports · 2017Article
- Influence of Early Onset of Alcohol Use on the Development of Adolescent Alcohol Problems: a Longitudinal Binational Study.Prevention science : the official journal of the Society for Prevention Research · 2017Article
- Neurodevelopmental Precursors and Consequences of Substance Use during Adolescence: Promises and Pitfalls of Longitudinal Neuroimaging Strategies.Frontiers in human neuroscience · 2016Article
- Temperament disturbances measured in infancy progress to substance use disorder 20 years later.Personality and individual differences · 2015Article
- Comorbidity and temporal relations of alcohol and cannabis use disorders from youth through adulthood.Drug and alcohol dependence · 2015Article
- Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder.Addictive behaviors · 2015Article
- A Long-Term Longitudinal Examination of the Effect of Early Onset of Alcohol and Drug Use on Later Alcohol Abuse.Substance abuse · 2015Article
- Gender differences in the developmental risk of onset of alcohol, nicotine, and marijuana use and the effects of nicotine and marijuana use on alcohol outcomes.Journal of studies on alcohol and drugs · 2014Observational
- A new approach to researching the etiology of cannabis use disorder: integrating transmissible and nontransmissible risk within a developmental framework.Substance abuse · 2014Article
- Longitudinal modeling of transmissible risk in boys who subsequently develop cannabis use disorder.The American journal of drug and alcohol abuse · 2013Article
- Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Age at the time of first alcohol and cannabis use was investigated in relation to a measure of transmissible (intergenerational) risk for addiction in childhood and development of alcohol use disorder (AUD) and cannabis use disorder (CUD). It was hypothesized that age at the time of first experience with either substance mediates the association between transmissible risk and subsequent diagnosis of both disorders. The Transmissible Liability Index (TLI; (Vanyukov et al., 2009) was administered to 339 10- to 12-year-old boys (n = 254) and girls (n = 85). Age at the time of first alcohol and cannabis use, and diagnosis of AUD and CUD, were prospectively tracked to age 22. Each standard deviation unit increase in TLI severity corresponded to a reduction in age of alcohol and cannabis use onset by 3.2 months and 4.6 months, respectively. Age at the time of first alcohol use mediated the association of TLI with both AUD and CUD. Parallel results were obtained for cannabis. Whereas transmissible risk is congenerous to both AUD and CUD, its magnitude was 7 times greater in youths who initiated substance use with cannabis. TLI predicts age of first use of alcohol and cannabis that is common to developing both AUD and CUD. The ramifications of these findings for prevention are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.