ArticleMolecular microbiology2013
YopK controls both rate and fidelity of Yop translocation.
Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Current Challenges inMicroorganisms · 2025Review
- Pathogenicity and virulence ofVirulence · 2024Review
- Article
- Bacterial subversion of NLR-mediated immune responses.Frontiers in immunology · 2022Review
- Heightened Virulence ofInfection and immunity · 2021Article
- Proteogenomic discovery of sORF-encoded peptides associated with bacterial virulence in Yersinia pestis.Communications biology · 2021Article
- Cell-type-specific hypertranslocation of effectors by the Pseudomonas aeruginosa type III secretion system.Molecular microbiology · 2021Article
- Effector-triggered immunity and pathogen sensing in metazoans.Nature microbiology · 2020Review
- Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Sweet host revenge: Galectins and GBPs join forces at broken membranes.Cellular microbiology · 2017Review
- Immunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike.Virulence · 2017Review
- Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.Infection and immunity · 2017Article
- Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Bacterial secretion systems and regulation of inflammasome activation.Journal of leukocyte biology · 2017Review
- The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.PLoS pathogens · 2016Article
- Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.Infection and immunity · 2016Article
- The Amino-Terminal Part of the Needle-Tip Translocator LcrV ofFrontiers in cellular and infection microbiology · 2016Article
- Illuminating Targets of Bacterial Secretion.PLoS pathogens · 2015Review
- Modulation of the host innate immune and inflammatory response by translocated bacterial proteins.Cellular microbiology · 2015Review
- Article
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Authors and funding
3 authors.
Funding
Abstract
Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to intoxicate host cells. The injection of T3SS substrates must be carefully controlled, and dysregulation leads to altered infection kinetics and early clearance of Y. pestis. While the sequence of events leading up to cell contact and initiation of translocation has received much attention, the regulatory events that take place after effector translocation is less understood. Here we show that the regulator YopK is required to maintain fidelity of substrate specificity, in addition to controlling translocation rate. YopK was found to interact with YopD within targeted cells during Y. pestis infection, suggesting that YopK's regulatory mechanism involves a direct interaction with the translocation pore. In addition, we identified a single amino acid in YopK that is essential for translocation rate regulation but is dispensable for maintaining fidelity of translocation. Furthermore, we found that expression of YopK within host cells was sufficient to downregulate translocation rate, but it did not affect translocation fidelity. Together, our data support a model in which YopK is a bifunctional protein whose activities are genetically and spatially distinct such that fidelity control occurs within bacteria and rate control occurs within host cells.
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