ArticleProceedings of the National Academy of Sciences of the United States of America1990
Effect of thyroid hormone on the accumulation of mRNA for skeletal and cardiac alpha-actin in hearts from normal and hypophysectomized rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Morphologic and Morphometric Study of the Heart and Its Great Arteries in the Common Pheasant (Phasianus colchicus).Veterinary medicine and science · 2026Article
- Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats.Saudi journal of biological sciences · 2019Article
- Article
- Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies.Journal of cellular and molecular medicine · 2009Article
- Developmental expression of the alpha-skeletal actin gene.BMC evolutionary biology · 2008Article
- Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.The Canadian journal of cardiology · 2006Review
- Hypertension and age-related changes in the heart. Implications for drug therapy.Drugs & aging · 1994Review
- Contractile protein gene expression in serum-free cultured adult rat cardiac myocytes.Pflugers Archiv : European journal of physiology · 1993Article
- Fibronectin expression in the normal and hypertrophic rat heart.The Journal of clinical investigation · 1992Article
- The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load.The Journal of clinical investigation · 1991Article
- Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.The Journal of clinical investigation · 1991Article
- Regulation of expression of contractile proteins with cardiac hypertrophy and failure.Molecular and cellular biochemistryArticle
- Regulation of myosin heavy chain and actin isogenes expression during cardiac growth.Molecular and cellular biochemistryArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal alpha-actin gene products are coexpressed with cardiac alpha-actins in cardiac tissue of adult humans, cows, and pigs; in prenatal rats; and during hypertrophy due either to increased hemodynamic load or the administration of alpha-adrenergic agonists. Because there is preferential synthesis of the beta-myosin heavy chain in each case, it has been suggested that the synthesis of skeletal alpha-actin in cardiac tissue is linked to that of beta-myosin heavy chain. To test this hypothesis, thyroid hormone, which causes cardiac hypertrophy with preferential synthesis of alpha-myosin heavy chain, was administered to normal and hypophysectomized rats. Animals were sacrificed from 2 to 24 hr after the injection of either 1 or 5 micrograms of hormone per 10 g of body weight. The relative amount of mRNA for skeletal and cardiac alpha-actin was measured by using the technique of primer extension. Thyroid hormone caused a rapid increase in the amount of skeletal alpha-actin mRNA relative to controls, more than 7 times in hearts from normal animals and 15 times in hearts from hypophysectomized animals. A small increase in cardiac alpha-actin mRNA also occurred. The rapid increase in transcripts for skeletal alpha-actin under conditions where the isoform of myosin heavy chain that is being synthesized is primarily alpha demonstrates independent patterns of activation of the actin and myosin heavy chain multigene families during cardiac growth in mammals.
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