Trial reportAlimentary pharmacology & therapeutics2013
Randomised clinical trial: symptoms of the irritable bowel syndrome are improved by a psycho-education group intervention.
Trial report in Alimentary pharmacology & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- [A Meta-Analysis on the Effects of Mind-Body Therapy on Patients with Irritable Bowel Syndrome].Journal of Korean Academy of Nursing · 2020Pooled it
- Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Review.Western journal of nursing research · 2018Pooled it
- A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome.Biological research for nursing · 2021Trial
- Trial
- Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety.World journal of gastroenterology · 2014Trial
- The Gut-Brain Axis-From Science to Clinical Practice.Gastro hep advances · 2026Review
- Validation of the menstrual sensitivity index in adolescents.Pain reports · 2025Article
- Nurse-led self-management support to improve symptom management and self-reported outcomes in people with irritable bowel syndrome.Interdisciplinary nursing research · 2024Article
- Factors That Predict Magnitude, Timing, and Persistence of Placebo-Like Response in Patients With Irritable Bowel Syndrome.Gastro hep advances · 2024Article
- Adult Stress Promotes Purinergic Signaling to Induce Visceral Pain in Rats with Neonatal Maternal Deprivation.Neuroscience bulletin · 2020Article
- Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020Review
- Irritable Bowel Syndrome: News from an Old Disorder.GE Portuguese journal of gastroenterology · 2020Review
- Psychotherapeutic Interventions in Irritable Bowel Syndrome.Frontiers in psychiatry · 2020Review
- Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity.Neuroscience bulletin · 2019Article
- Effects of Self-Management Education on Self-Efficacy and Quality of Life in Patients with Ulcerative Colitis: A Randomized Controlled Clinical Trial.International journal of community based nursing and midwifery · 2019Article
- Irritable Bowel Syndrome: Patient-Provider Interaction and Patient Education.Journal of clinical medicine · 2018Review
- Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice.United European gastroenterology journal · 2017Review
- Effects of Cognitive Behavior Therapy on Heart Rate Variability in Young Females with Constipation-predominant Irritable Bowel Syndrome: A Parallel-group Trial.Journal of neurogastroenterology and motility · 2017Article
- Epigenetic Mechanisms of Integrative Medicine.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Using Telehealth to Train Providers of a Cancer Support Intervention.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundEvidence supports the effectiveness of cognitive behavioural approaches in improving the symptoms of the irritable bowel syndrome (IBS). Duration, cost and resistance of many patients towards a psychological therapy have limited their acceptance.
aimTo evaluate the effectiveness of a psycho-educational intervention on IBS symptoms.
methodsSixty-nine IBS patients (72% female) were randomised to an intervention or a wait-list control group. The IBS class consisted of education on a biological mind body disease model emphasising self-efficacy and practical relaxation techniques.
resultsPatients in the intervention showed significant improvement on GI symptom severity, visceral sensitivity, depression and QoL postintervention and most of these gains were maintained at 3-month follow-up (Hedge's g = -0.46-0.77). Moderated mediation analyses indicated change in anxiety, visceral sensitivity, QoL and catastrophising due to the intervention had moderate mediation effects (Hedge's g = -0.38 to -0.60) on improvements in GI symptom severity for patients entering the trial with low to average QoL. Also, change in GI symptom severity due to the intervention had moderate mediation effects on improvements in QoL especially in patients with low to average levels of QoL at baseline. Moderated mediation analyses indicated mediation was less effective for patients entering the intervention with high QoL.
conclusionsA brief psycho-educational group intervention is efficacious in changing cognitions and fears about the symptoms of the irritable bowel syndrome, and these changes are associated with clinically meaningful improvement in symptoms and quality of life. The intervention seems particularly tailored to patients with low to moderate quality of life baseline levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.