ArticleJournal of clinical and diagnostic research : JCDR2012
Cytomegalovirus occurrence in chronic periodontitis and in carcinoma of the cervix: an exploratory study.
Article in Journal of clinical and diagnostic research : JCDR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Human Cytomegalovirus Oncoprotection across Diverse Populations, Tumor Histologies, and Age Groups: The Relevance for Prospective Vaccinal Therapy.International journal of molecular sciences · 2024Article
- Proteome Analysis of Molecular Events in Oral Pathogenesis and Virus: A Review with a Particular Focus on Periodontitis.International journal of molecular sciences · 2020Review
- Prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo explore the following in a group of carcinoma cervix patients with chronic periodontitis: The possible association of the Human Cytomegalovirus (HCMV) in chronic periodontitis and carcinoma of the cervix by examining the presence of HCMV (Human Cytomegalovirus) in saliva, Gingival Crevicular Fluid (G.C.F.) and in cervical biopsy samples and by comparing the clinical parameters among the Human Cytomegalovirus(HCMV) detected and the undetected sites. The possible association of chronic periodontitis and carcinoma of the cervix by assessing the common occurrence of HCMV in saliva, GCF and cervical biopsies. MATERIAL AND
methodsSixteen female subjects who were aged 35 to 65 years, who were diagnosed with carcinoma of the cervix were selected. All the subjects underwent a clinical evaluation for their periodontal conditions. Cervical biopsies, saliva and GCF samples were obtained from all the participants and these were subjected to HCMV detection by using the nested PCR method.
resultsHCMV has been detected in the cervical biopsies of 68.75 % patients, in the GCF samples of 75 % patients and in the saliva samples of 37.5 % patients. The clinical parameters i.e. probing pocket depth (P<0.008) and the clinical attachment level (P<0.026) were statistically significant in the GCF samples of the sites which were positive for HCMV as compared to those in the sites which were negative for HCMV. In 56% patients, HCMV was detected in both the cervical biopsies and the GCF samples. In 25% patients, HCMV was detected in both the cervical biopsies and the saliva samples.
conclusionThe results are suggestive of a possible association of the HCMV occurrence in chronic periodontitis and a possible association of the HCMV occurrence and carcinoma of the cervix. An association between chronic periodontitis and carcinoma of the cervix cannot be elucidated with the available data, since the values are statistically insignificant. Hence, further research incorporating systemic inflammatory parameters would be necessary.
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