ArticleACS macro letters2012
Poly[(ethylene oxide)-co-(methylene ethylene oxide)]: A hydrolytically-degradable poly(ethylene oxide) platform.
Article in ACS macro letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Polymeric Nanoparticles for Drug Delivery.Chemical reviews · 2024Review
- Engineering protein-based therapeutics through structural and chemical design.Nature communications · 2023Review
- Using Triethylborane to Manipulate Reactivity Ratios in Epoxide-Anhydride Copolymerization: Application to the Synthesis of Polyethers with Degradable Ester Functions.Molecules (Basel, Switzerland) · 2022Article
- Acid-Cleavable Poly(ethylene glycol) Hydrogels Displaying Protein Release at pH 5.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Poly(ethylene glycol)s With a Single Cinnamaldehyde Acetal Unit for Fabricating Acid-Degradable Hydrogel.Frontiers in chemistry · 2020Article
- Polymer-drug conjugate therapeutics: advances, insights and prospects.Nature reviews. Drug discovery · 2019Review
- Polymeric Nanostructures for Imaging and Therapy.Chemical reviews · 2015Review
- Protein-polymer conjugation-moving beyond PEGylation.Current opinion in chemical biology · 2015Review
- Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization.European polymer journal · 2015Article
- Synthetic Strategy for Preparing Chiral Double-semicrystalline Polyether Block Copolymers.Polymer chemistry · 2015Article
- Holistic assessment of covalently labeled core-shell polymeric nanoparticles with fluorescent contrast agents for theranostic applications.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Differential immunotoxicities of poly(ethylene glycol)- vs. poly(carboxybetaine)-coated nanoparticles.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs.Journal of materials chemistry. B · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A facile method for imparting hydrolytic degradability to poly(ethylene oxide) (PEO), compatible with current PEGylation strategies, is presented. By incorporating methylene ethylene oxide (MEO) units into the parent PEO backbone, complete degradation was defined by the molar incorporation of MEO, and the structure of the degradation byproducts was consistent with an acid-catalyzed vinyl-ether hydrolysis mechanism. The hydrolytic degradation of poly[(ethylene oxide)-co-(methylene ethylene oxide)] was pH-sensitive, with degradation at pH 5 being significantly faster than at pH 7.4 at 37 °C in PBS buffer while long-term stability could be obtained in either the solid-state or at pH 7.4 at 6 °C.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.