ArticleMediterranean journal of hematology and infectious diseases2012
Malaria in children.
Article in Mediterranean journal of hematology and infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Pooled prevalence of malaria and associated factors among vulnerable populations in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies.Malaria journal · 2023Pooled it
- Global trend of Plasmodium malariae and Plasmodium ovale spp. malaria infections in the last two decades (2000-2020): a systematic review and meta-analysis.Parasites & vectors · 2021Pooled it
- Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania.Malaria journal · 2020Trial
- How the One Health approach can make effective the World Health Organization's recommendations on integrated management of childhood illnesses: Case of community-based home management of malaria in theDialogues in health · 2026Article
- Malaria and bacteremia in febrile children presenting at a teaching hospital in Kumasi, Ghana.BMC infectious diseases · 2026Article
- Malaria in children aged <6 months: a narrative review of current evidence, recommendations and practice gaps.Tropical medicine and health · 2026Review
- Who uses the only mosquito net? Sex and age disparities.Tropical medicine and health · 2026Article
- Malaria: a review on its current epidemiological status and management strategies.Malaria journal · 2026Review
- Epidemiology of imported malaria in an area of North-Eastern Italy (2016-2025): clinical focus on cerebral malaria.Le infezioni in medicina · 2026Article
- Highly conserved Plasmodium vivax genomes in Duffy-negative individuals from Sudan.Scientific reports · 2025Article
- Optimal control analysis of malaria infection in children under 5 years and pregnant women under the influence of temperature.Malaria journal · 2025Article
- Increased Plasmodium falciparum EBA175RIII-V antibody titres despite a 13-month malaria mass testing, treatment, and tracking intervention in a high malaria endemic community in Ghana.Malaria journal · 2025Article
- Article
- Factors influencing fever care-seeking for children under five years of age in The Gambia: a secondary analysis of 2019-20 DHS data.Malaria journal · 2024Article
- The use of the WHO criteria to detect severe malaria among patients clinically diagnosed with uncomplicated malaria.PLOS global public health · 2024Article
- Age-specific malaria vulnerability and transmission reservoir among children.Global pediatrics · 2023Review
- Knowledge, attitudes and practices regarding malaria prevention and control in communities in the Eastern Region, Ghana, 2020.PloS one · 2023Article
- Bayesian spatio-temporal modelling and mapping of malaria and anaemia among children between 0 and 59 months in Nigeria.Malaria journal · 2022Article
- Spatio-Temporal Variation of Malaria Incidence and Risk Factors in West Gojjam Zone, Northwest Ethiopia.Environmental health insights · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review is focused on childhood specific aspects of malaria, especially in resource-poor settings. We summarise the actual knowledge in the field of epidemiology, clinical presentation, diagnosis, management and prevention.These aspects are important as malaria is responsible for almost a quarter of all child death in sub-Saharan Africa. Malaria control is thus one key intervention to reduce childhood mortality, especially as malaria is also an important risk factor for other severe infections, namely bacteraemia.In children symptoms are more varied and often mimic other common childhood illness, particularly gastroenteritis, meningitis/encephalitis, or pneumonia. Fever is the key symptom, but the characteristic regular tertian and quartan patterns are rarely observed. There are no pathognomonic features for severe malaria in this age group. The well known clinical (fever, impaired consciousness, seizures, vomiting, respiratory distress) and laboratory (severe anaemia, thrombocytopenia, hypoglycaemia, metabolic acidosis, and hyperlactataemia) features of severe falciparum malaria in children, are equally typical for severe sepsis.Appropriate therapy (considering species, resistance patterns and individual patient factors) - possibly a drug combination of an artemisinin derivative with a long-acting antimalarial drug - reduces treatment duration to only three days and should be urgently started.While waiting for the results of ongoing vaccine trials, all effort should be made to better implement other malaria-control measures like the use of treated bed-nets, repellents and new chemoprophylaxis regimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.