ArticleOncology letters2012
Comparison of L1 expression and secretion in glioblastoma and neuroblastoma cells.
Article in Oncology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.BMC cancer · 2019Article
- Increased L1CAM (CD171) levels are associated with glioblastoma and metastatic brain tumors.Medicine · 2018Article
- Tumorigenic proteins upregulated in the MYCN-amplified IMR-32 human neuroblastoma cells promote proliferation and migration.International journal of oncology · 2018Article
- Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation.Cellular oncology (Dordrecht, Netherlands) · 2016Article
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Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of cell adhesion molecule L1 has been identified in a vast spectrum of tumors; however, its expression pattern with regard to tumor type is rarely discussed. In the present study, we studied L1 levels in human glioblastomas and neuroblastomas, and compared the expression and secretion of L1 in human glioblastoma U87-MG and neuroblastoma SK-N-SH cells. Immunofluorescence staining revealed different grades of L1 staining in human glioblastoma and neuroblastoma samples. In U87-MG cells, full-length L1 was weakly detected in cell lysates (CLs), while greater levels of abundant soluble L1 were confined in conditioned culture medium (CCM). In contrast, higher levels of full-length L1 were confined in SK-N-SH CLs, while almost no soluble forms of L1 were detected in CCM. Our data indicates various expression patterns of L1 in U87-MG and SK-N-SH cells, which may underlie the different malignancies of the two neural tumor types and further stress the importance of soluble L1-mediated signaling pathways in cell malignancy.
Identifiers
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Registered trials
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