ArticleHand (New York, N.Y.)2011
Tendon injury produces changes in SSCT and nerve physiology similar to carpal tunnel syndrome in an in vivo rabbit model.
Article in Hand (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Comparison of the establishment of a rabbit model of carpal tunnel syndrome under ultrasound-guided and landmark-guided methods.Scientific reports · 2025Article
- Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats.International journal of molecular sciences · 2024Article
- Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury.International journal of molecular sciences · 2023Article
- Median nerve conduction studies in rabbits.BMC neuroscience · 2020Article
- The biomechanics of subsynovial connective tissue in health and its role in carpal tunnel syndrome.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2018Review
- Development of a hyperelastic material model of subsynovial connective tissue using finite element modeling.Journal of biomechanics · 2016Article
- Carpal tunnel syndrome pathophysiology: role of subsynovial connective tissue.Journal of wrist surgery · 2014Article
- Article
- A knowledge-based approach for carpal tunnel segmentation from magnetic resonance images.Journal of digital imaging · 2013Article
- The effect of time after shear injury on the subsynovial connective tissue and median nerve within the rabbit carpal tunnel.Hand (New York, N.Y.) · 2013Article
- Subsynovial connective tissue is sensitive to surgical interventions in a rabbit model of carpal tunnel syndrome.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe etiology of carpal tunnel syndrome (CTS) remains idiopathic in many cases. Noninflammatory fibrosis of the subsynovial connective tissue (SSCT) within the carpal tunnel is common in CTS, and some clinicians have hypothesized that this fibrosis might be a cause rather than an effect of CTS. An animal model in which to test this hypothesis would be useful. The principal objective of this study was to investigate the effect of a surgical injury on SSCT fibrosis and median nerve function within the carpal tunnel in an in vivo rabbit model.
methodsRabbits were sacrificed 12 weeks after surgery and were evaluated by mechanical testing, histology, transmission and scanning electron microscopy, and electrophysiology.
resultsSSCT fibroblast density (p < 0.0001) and collagen fiber size (p = 0.0004) were significantly higher, and the median nerve distal motor amplitude was significantly lower (p = 0.0018), in the tendon injury group SSCT than in either the sham or control groups.
conclusionsOur findings are similar to those seen in patients with carpal tunnel syndrome and suggest that the tendon injury procedure may be the basis of a new animal model of SSCT injury and, possibly, CTS.
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