ArticleJournal of pain research2012
Melatonin administration reduces inflammatory pain in rats.
Article in Journal of pain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of local melatonin application on post-extraction sockets after third molar surgery. A pilot study.Medicina oral, patologia oral y cirugia bucal · 2014Trial
- Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.BMC pharmacology & toxicology · 2014Trial
- Circadian dysfunction and Alzheimer's disease - An updated review.Aging medicine (Milton (N.S.W)) · 2023Article
- Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis.Scientific reports · 2023Article
- Review
- Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus.Life (Basel, Switzerland) · 2022Article
- Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models.Purinergic signalling · 2020Article
- Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice.Theranostics · 2017Article
- Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats.Inflammation · 2016Article
- The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination.Molecular neurobiology · 2016Article
- The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects.BioMed research international · 2015Review
- Combined neuromodulatory interventions in acute experimental pain: assessment of melatonin and non-invasive brain stimulation.Frontiers in behavioral neuroscience · 2015Article
- The use of non-narcotic pain medication in pediatric gastroenterology.Paediatric drugs · 2014Review
- Melatonin in perioperative medicine: Current perspective.Saudi journal of anaesthesia · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In view of the broad range of effects attributed to melatonin, this study evaluated its analgesic effect on inflammatory pain induced by complete Freund's adjuvant (CFA) in Wistar rats. Inflammation was induced by intradermal CFA injection in the hind paw of all animals, which were then divided into two groups that received either 60 mg/kg of melatonin or vehicle (1% alcohol in saline), intraperitoneally, for three days. The analgesic effect of melatonin was assessed by the hot-plate test, immediately and thereafter at 30, 60, 90, and 120 minutes after the first administration and 24 hours after once-daily administration for 2 more days. After CFA injection, melatonin administration increased withdrawal latency at 60 minutes after the first dose. After the end of treatment, melatonin showed a significant analgesic effect on inflammatory pain. This study paves the way for exploration of how brief courses of treatment could improve this analgesic effect in the late phases of inflammatory pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.