ArticleApplied and environmental microbiology2013
Adaptation and heterogeneity of Escherichia coli MC1000 growing in complex environments.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Using TraDIS as a complementary approach to long term evolution for mapping adaptive mutations in Escherichia coli.PLoS genetics · 2026Article
- Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering.Nature communications · 2023Article
- Metabolic adaptation to consume butyrate under prolonged resource exhaustion.PLoS genetics · 2023Article
- Habitat heterogeneity induced by pyrogenic organic matter in wildfire-perturbed soils mediates bacterial community assembly processes.The ISME journal · 2021Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Article
- Genetic Adaptation to Growth Under Laboratory Conditions inFrontiers in microbiology · 2018Article
- Dynamics and genetic diversification ofPeerJ · 2017Article
- Acid-adapted strains of Escherichia coli K-12 obtained by experimental evolution.Applied and environmental microbiology · 2015Article
- Mutations in global regulators lead to metabolic selection during adaptation to complex environments.PLoS genetics · 2014Article
- Plasticity predicts evolution in a marine alga.Proceedings. Biological sciences · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
In a study aiming to assess bacterial evolution in complex growth media, we evaluated the long-term adaptive response of Escherichia coli MC1000 in Luria-Bertani (LB) medium. Seven parallel populations were founded and followed over 150 days in sequential batch cultures under three different oxygen conditions (defined environments), and 19 evolved forms were isolated. The emergence of forms with enhanced fitness was evident in competition experiments of all evolved forms versus the ancestral strain. The evolved forms were then subjected to phenotypic and genomic analyses relative to the ancestor. Profound changes were found in their phenotypes as well as whole-genome sequences. Interestingly, considerable heterogeneity was found at the intrapopulational level. However, consistently occurring parallel adaptive responses were found across all populations. The evolved forms all contained a mutation in galR, a repressor of the galactose operon. Concomitantly, the new forms revealed enhanced growth on galactose as well as galactose-containing disaccharides. This response was likely driven by the LB medium.
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