ArticleMolecular biology and evolution2013
Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- Recombination plasticity in response to temperature variation in reptiles.PLoS genetics · 2025Article
- Patterns of chromosome evolution in ruminants.Molecular ecology · 2024Article
- Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9.Molecular biology and evolution · 2024Article
- Genomic Architecture Predicts Tree Topology, Population Structuring, and Demographic History in Amazonian Birds.Genome biology and evolution · 2024Article
- Unraveling haplotype errors in the DFNA33 locus.Frontiers in genetics · 2023Article
- The Genomic Landscapes of Desert Birds Form over Multiple Time Scales.Molecular biology and evolution · 2022Article
- Runs of homozygosity in Sable Island feral horses reveal the genomic consequences of inbreeding and divergence from domestic breeds.BMC genomics · 2022Article
- 3D chromatin remodelling in the germ line modulates genome evolutionary plasticity.Nature communications · 2022Article
- Chromosome size affects sequence divergence between species through the interplay of recombination and selection.Evolution; international journal of organic evolution · 2022Article
- Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.Molecular cell · 2021Article
- The impact of chromosomal fusions on 3D genome folding and recombination in the germ line.Nature communications · 2021Article
- Article
- Chromosome-Scale Genome Assemblies of Aphids Reveal Extensively Rearranged Autosomes and Long-Term Conservation of the X Chromosome.Molecular biology and evolution · 2021Article
- Chromosomal evolution in Raphicerus antelope suggests divergent X chromosomes may drive speciation through females, rather than males, contrary to Haldane's rule.Scientific reports · 2021Article
- Article
- Formation and diversification of a paradigm biosynthetic gene cluster in plants.Nature communications · 2020Article
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- Article
- Comparing local ancestry inference models in populations of two- and three-way admixture.PeerJ · 2020Article
- Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long-standing question in evolutionary biology concerns the effect of recombination in shaping the genomic architecture of organisms and, in particular, how this impacts the speciation process. Despite efforts employed in the last decade, the role of chromosomal reorganizations in the human-chimpanzee speciation process remains unresolved. Through whole-genome comparisons, we have analyzed the genome-wide impact of genomic shuffling in the distribution of human recombination rates during the human-chimpanzee speciation process. We have constructed a highly refined map of the reorganizations and evolutionary breakpoint regions in the human and chimpanzee genomes based on orthologous genes and genome sequence alignments. The analysis of the most recent human and chimpanzee recombination maps inferred from genome-wide single-nucleotide polymorphism data revealed that the standardized recombination rate was significantly lower in rearranged than in collinear chromosomes. In fact, rearranged chromosomes presented significantly lower recombination rates than chromosomes that have been maintained since the ancestor of great apes, and this was related with the lineage in which they become fixed. Importantly, inverted regions had lower recombination rates than collinear and noninverted regions, independently of the effect of centromeres. Our observations have implications for the chromosomal speciation theory, providing new evidences for the contribution of inversions in suppressing recombination in mammals.
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