ArticleEnvironmental health perspectives2013
Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.Public health nutrition · 2020Pooled it
- Article
- Toxicological effects of acrylamide on oocyte maturation and subsequent embryonic development in a porcine model.Biology direct · 2026Article
- Prenatal exposure to acrylamide and metabolic health at 20 years of age A biomarker-based Danish cohort study.Environment international · 2026Article
- Article
- Estimation of the Dietary Acrylamide Exposure of the Turkish Population: An Emerging Threat for Human Health.Nutrients · 2024Article
- Dietary acrylamide exposure and health risk assessment of pregnant women: A case study from Türkiye.Food science & nutrition · 2024Article
- From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach.Nutrition reviews · 2023Review
- Dietary Acrylamide Exposure and Cancer Risk: A Systematic Approach to Human Epidemiological Studies.Foods (Basel, Switzerland) · 2023Review
- Prenatal acrylamide exposure results in time-dependent changes in liver function and basal hematological, and oxidative parameters in weaned Wistar rats.Scientific reports · 2022Article
- Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies.Toxics · 2022Article
- Article
- Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity.Environmental science and pollution research international · 2022Article
- Association between acrylamide exposure and the odds of developmental disabilities in children: A cross-sectional study.Frontiers in public health · 2022Article
- Article
- A Review of Dietary Intake of Acrylamide in Humans.Toxics · 2021Review
- Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes.Environmental health : a global access science source · 2021Article
- Article
- Are AAMA and GAMA Levels in Urine after Childbirth a Suitable Marker to Assess Exposure to Acrylamide from Passive Smoking during Pregnancy?-A Pilot Study.International journal of environmental research and public health · 2020Article
- Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis.World journal of gastroenterology · 2020Review
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12 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAcrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans.
objectivesWe assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight.
methodsThis study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes.
resultsAcrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was -25.7 g (95% CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide- and glycidamide-Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively).
conclusionsLowering dietary acrylamide intake during pregnancy may improve fetal growth.
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