Evidence map›Paper›PMID 23204254›Full record

ReviewAmerican journal of respiratory and critical care medicine2013

Chronic bronchitis and chronic obstructive pulmonary disease.

Victor Kim, Gerard J Criner

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06086730 (Comparison Of Blow Bottle Positive Expiratory Pressure), which is not on this map. Cited by 251 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed, 5 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06086730 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison Of Blow Bottle Positive Expiratory Pressure (BBPEP) Versus Acapella on Oxygenation ,Peak Expiratory Flow Rate (PEFR) Among Patient With Chronic Bronchitis

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled36ConditionsChronic BronchitisArmsblow bottle positive expiratory pressure, acapella
3 · Its place in the literature

Who cites it

251 citing papers in PubMed, 5 syntheses or guidelines pooled it, 498 citations in OpenAlex.

  1. Pooled it
  2. Systematic review and meta‑analysis of factors predicting postoperative lung function after lung cancer resection.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024
    Pooled it
  3. The European respiratory journal · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
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  11. Observational
  12. Article
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  15. Review
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  18. Antioxidants (Basel, Switzerland) · 2026
    Article
  19. 4-Hydroxynonenal, a Potential Biomarker for Lung Inflammatory Diseases.International journal of molecular sciences · 2026
    Review
  20. Article

191 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Victor KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. victor.kim@tuhs.temple.edu
Gerard J Criner
Temple University · US

Funding

Th17 inflammation is responsible for mucous metaplasia in COPDK23HL094696 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KIM, VICTOR · 2011 to 2014
$563k
NHLBI NIH HHS 1K23HL094696-01A2NHLBI NIH HHS K23 HL094696
6 · The paper itself

Abstract

Chronic bronchitis (CB) is a common but variable phenomenon in chronic obstructive pulmonary disease (COPD). It has numerous clinical consequences, including an accelerated decline in lung function, greater risk of the development of airflow obstruction in smokers, a predisposition to lower respiratory tract infection, higher exacerbation frequency, and worse overall mortality. CB is caused by overproduction and hypersecretion of mucus by goblet cells, which leads to worsening airflow obstruction by luminal obstruction of small airways, epithelial remodeling, and alteration of airway surface tension predisposing to collapse. Despite its clinical sequelae, little is known about the pathophysiology of CB and goblet cell hyperplasia in COPD, and treatment options are limited. In addition, it is becoming increasingly apparent that in the classic COPD spectrum, with emphysema on one end and CB on the other, most patients lie somewhere in the middle. It is known now that many patients with severe emphysema can develop CB, and small airway pathology has been linked to worse clinical outcomes, such as increased mortality and lesser improvement in lung function after lung volume reduction surgery. However, in recent years, a greater understanding of the importance of CB as a phenotype to identify patients with a beneficial response to therapy has been described. Herein we review the epidemiology of CB, the evidence behind its clinical consequences, the current understanding of the pathophysiology of goblet cell hyperplasia in COPD, and current therapies for CB.

Indexed as

Adrenergic beta-AgonistsAnti-Bacterial AgentsAntioxidantsBronchitis, ChronicCholinergic AntagonistsDisease ProgressionExpectorantsGlucocorticoidsGoblet CellsHumansMucusPhosphodiesterase InhibitorsPulmonary Disease, Chronic ObstructiveSmokingSmoking CessationXanthinesAdrenergic beta-AgonistsAnti-Bacterial AgentsAntioxidantsCholinergic AntagonistsExpectorantsGlucocorticoidsmethylxanthinePhosphodiesterase InhibitorsXanthines

Identifiers

PMID23204254
PMCPMC4951627
OpenAlexW2143763541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.