ArticleDiabetes care2013
C-peptide levels are associated with mortality and cardiovascular mortality in patients undergoing angiography: the LURIC study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- C-peptide as an important biomarker in diabetes management: The need for standardization of its measurement.Diabetes, obesity & metabolism · 2026Article
- C-peptide in Precision Diabetes Care and Beyond: A Comprehensive Review.Clinical medicine insights. Endocrinology and diabetes · 2026Review
- Non-Linear Relationship Between Fasting C-Peptide and Retinopathy in Patients with Type 2 Diabetes Mellitus - A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The association between C-peptide and atrial cardiomyopathy in nondiabetic adults: results from NHANES III.Heart and vessels · 2023Article
- The role of C-peptide in diabetes and its complications: an updated review.Frontiers in endocrinology · 2023Review
- Serum C-peptide level and the risk of cardiovascular diseases mortality and all-cause mortality: a meta-analysis and systematic review.Frontiers in cardiovascular medicine · 2023Review
- C-peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective.Diabetes, obesity & metabolism · 2022Review
- Association of low fasting C-peptide levels with cardiovascular risk, visit-to-visit glucose variation and severe hypoglycemia in the Veterans Affairs Diabetes Trial (VADT).Cardiovascular diabetology · 2021Article
- Lentivirus Mediated Pancreatic Beta-Cell-Specific Insulin Gene Therapy for STZ-Induced Diabetes.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Associations of serum C-peptide and insulin-like growth factor binding proteins-3 with breast cancer deaths.PloS one · 2020Article
- [C-peptide and cardiovascular mortality: systematic review and meta-analysisPéptido C y mortalidad cardiovascular: revisión sistemática y metanálisis].Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- C-Peptide and cardiovascular risk factors among young adults in a southern Brazilian cohort.BMC endocrine disorders · 2018Article
- [Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- The Role of C-Peptide as Marker of Cardiometabolic Risk in Women With Polycystic Ovary Syndrome: A Controlled Study.Journal of clinical medicine research · 2018Article
- The Association of Fasting Glucose, Insulin, and C-Peptide, with 19-Year Incidence of Coronary Heart Disease in Older Japanese-American Men; the Honolulu Heart Program.Geriatrics (Basel, Switzerland) · 2018Article
- Implementing a Reference Measurement System for C-Peptide: Successes and Lessons Learned.Clinical chemistry · 2017Review
- A Practical Review of C-Peptide Testing in Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women.International journal of medical sciences · 2016Article
- Serum levels of C-peptide are associated with coronary artery calcification in patients with rheumatoid arthritis.Rheumatology international · 2015Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveC-peptide is a proinsulin cleavage product released from the pancreas in amounts equimolar to insulin, and elevated levels of C-peptide have been found in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest that C-peptide could play a causal role in the pathophysiology of vascular disease, but nothing is known about the prognostic value of C-peptide concentrations in the circulation. RESEARCH DESIGN AND
methodsWe examined whether C-peptide is associated with cardiovascular and total mortality in 2,306 patients from the Ludwigshafen Risk and Cardiovascular Health Study who underwent coronary angiography at baseline (1997-2000).
resultsDuring a mean follow-up of 7.6 years, 440 deaths (19.1%) occurred, 252 (10.9%) of which were due to cardiovascular causes. Age- and sex-adjusted hazard ratios (HRs) in the third compared with the first tertile of C-peptide were 1.46 (95% CI 1.15-1.85; P = 0.002) for all cause and 1.58 (1.15-2.18; P = 0.005) for cardiovascular mortality. After further adjustment for common risk factors as well as markers of glucose metabolism, these HRs remained significant at 1.46 (1.10-1.93; P = 0.008) and 1.55 (1.07-2.24; P = 0.022), respectively. Moreover, patients in higher tertiles of C-peptide exhibited higher levels of markers of endothelial dysfunction and atherosclerosis as well as a more severe extent of coronary lesions.
conclusionsIn patients undergoing coronary angiography, C-peptide levels are independently associated with all cause and cardiovascular mortality as well as presence and severity of coronary artery disease. Further studies are needed to examine a potential causal role of C-peptide in atherogenesis in humans.
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