ArticleCancer research2013
Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures.
Article in Cancer research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
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- Regulation of ERα-dependent breast cancer metastasis by a miR-29a signaling.Journal of experimental & clinical cancer research : CR · 2023Article
- Inhibition of GATA2 in prostate cancer by a clinically available small molecule.Endocrine-related cancer · 2021Article
- Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality inClinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Article
- Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool.Stem cell reports · 2019Article
- Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone.The Journal of clinical investigation · 2018Article
- SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.Oncogene · 2017Article
- v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.Cancer research · 2016Article
- Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells.Cancer research · 2016Article
- The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.Cancer research · 2015Article
- CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.Cancer research · 2014Article
- CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.Oncotarget · 2014Article
- SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression.Virchows Archiv : an international journal of pathology · 2014Article
- Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint.Cancer research · 2014Article
- Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Gene signatures distinguish stage-specific prostate cancer stem cells isolated from transgenic adenocarcinoma of the mouse prostate lesions and predict the malignancy of human tumors.Stem cells translational medicine · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Herein, murine prostate cancer cell lines, generated via selective transduction with a single oncogene (c-Myc, Ha-Ras, and v-Src), showed oncogene-specific prostate cancer molecular signatures that were recapitulated in human prostate cancer and developed lung metastasis in immune-competent mice. Interrogation of two independent retrospective cohorts of patient samples using the oncogene signature showed an ability to distinguish tumor from normal prostate with a predictive value for prostate cancer of 98% to 99%. In a blinded study, the signature algorithm showed independent substratification of reduced recurrence-free survival by Kaplan-Meier analysis. The generation of new oncogene-specific prostate cancer cell lines that recapitulate human prostate cancer gene expression, which metastasize in immune-competent mice, are a valuable new resource for testing targeted therapy, whereas the molecular signatures identified herein provides further value over current gene signature markers of prediction and outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.