Trial reportJournal of the American Dental Association (1939)2012
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Trial report in Journal of the American Dental Association (1939), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Assessing the environmental impact of clear aligner therapy: a scoping review.Frontiers in dental medicine · 2026Pooled it
- Toxicity of resin-matrix composites in a dental clinical setting.Odontology · 2025Pooled it
- Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?-A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- A Systematic Review of Exposure to Bisphenol A from Dental Treatment.JDR clinical and translational research · 2019Pooled it
- Dental composite materials and renal function in children.British dental journal · 2014Trial
- Dental sealants and flowable composite restorations and psychosocial, neuropsychological, and physical development in children.Pediatric dentistryTrial
- Bisphenol-A Release from Modern Resin-Based Dental Composites: A Time-Dependent In Vitro Assessment.Polymers · 2026Article
- Environmental impact of dental amalgam and alternative restorative materials: a systematic review.BDJ open · 2026Review
- Dental composite-resin materials and oral-systemic health: clinical toxicology insights.Frontiers in public health · 2026Review
- Bisphenol A in contemporary dentistry: from material chemistry and exposure pathways to potential clinical relevance-a comprehensive narrative review.Frontiers in dental medicine · 2026Review
- Review
- Article
- Influence of Polymerization Protocol on Adhesion and Proliferation ofBiomedicines · 2024Article
- Degradation products of resin-based materials detected in saliva in vivo.Clinical oral investigations · 2023Observational
- Monomer release from dental restorative materials containing dimethacrylate resin after bleaching.Clinical oral investigations · 2022Article
- Resin-based composite materials: elution and pollution.British dental journal · 2022Review
- Effect of an elastomeric urethane monomer on BisGMA-free resin composites containing different co-initiators.Clinical oral investigations · 2022Article
- Effects of Bisphenol A Released From Composite Fillings on Reproductive Hormone Levels in Men.International dental journal · 2021Article
- Investigation of the Impact of Dental Care via Composite Resin Restoration among Children with Attention Deficit Hyperactivity Disorder: A Registry-Based Nested Case-Control Study.Healthcare (Basel, Switzerland) · 2021Article
- A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment.Journal of dental research · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundBisphenol A (BPA) and other related chemical compounds may be components used in the manufacturing process of resin-based composite dental restorative material. The purpose of the authors' study was to assess salivary and urinary concentrations of BPA and other compounds before and after placement of resin-based composite dental restorations.
methodsThe authors collected saliva and urine from 172 participants receiving composite restorations before and as long as 30 hours after placement of composite restorations. The authors analyzed saliva specimens from 151 participants and urine specimens from 171 participants for concentrations of BPA and five related compounds by using liquid chromatography/mass spectrometry (LC/MS).
resultsSalivary concentrations of BPA and some related compounds increased immediately (within one hour) after composite placement. Salivary concentrations of BPA and most study compounds returned to prerestoration levels within eight hours after composite placement. With the exception of a 43 percent increase in BPA, concentrations of the study compounds in urine returned to prerestoration levels nine to 30 hours after restoration placement. Concentrations in saliva were lower when a rubber dam was used; however, rubber dam use appeared to have no effect on urinary concentrations of the measured compounds during the study period. The authors observed similar changes in study compound levels in both saliva and urine between participants who received anterior restorations and those who received posterior restorations.
conclusionsPlacement of resin-based composite restorations was associated with detectable increases in saliva of BPA and other study compounds within one hour after restoration placement and an increased concentration of BPA in urine nine to 30 hours after restoration placement. Rubber dam use did not reduce the absorption of BPA (measured as BPA level in urine) during the study. CLINICAL IMPLICATIONS: Additional studies are needed to address how long BPA levels in urine associated with composite placement remain elevated to aid in better understanding of the clearance rates of BPA and other study compounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.