ArticleNucleic acids research2013
EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Lipid nanoparticle delivery of TALEN mRNA targeting LPA causes gene disruption and plasma lipoprotein(a) reduction in transgenic mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- The comparison of ZFNs, TALENs, and SpCas9 by GUIDE-seq in HPV-targeted gene therapy.Molecular therapy. Nucleic acids · 2021Article
- Genetic tool development and systemic regulation in biosynthetic technology.Biotechnology for biofuels · 2018Review
- Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.Molecular cell · 2016Review
- Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Review
- CrisprGE: a central hub of CRISPR/Cas-based genome editing.Database : the journal of biological databases and curation · 2015Article
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- Targeted genome engineering techniques in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Review
- Use of the heteroduplex mobility assay and cell sorting to select genome sequences of the CCR5 gene in HEK 293T cells edited by transcription activator-like effector nucleases.Genetics and molecular biology · 2014Article
- Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish.Psychopharmacology · 2014Review
- Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila.G3 (Bethesda, Md.) · 2013Article
- An efficient strategy for TALEN-mediated genome engineering in Drosophila.Nucleic acids research · 2013Article
- Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.Nucleic acids research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the construction of engineered endonuclease database (EENdb) (http://eendb.zfgenetics.org/), a searchable database and knowledge base for customizable engineered endonucleases (EENs), including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). EENs are artificial nucleases designed to target and cleave specific DNA sequences. EENs have been shown to be a very useful genetic tool for targeted genome modification and have shown great potentials in the applications in basic research, clinical therapies and agricultural utilities, and they are specifically essential for reverse genetics research in species where no other gene targeting techniques are available. EENdb contains over 700 records of all the reported ZFNs and TALENs and related information, such as their target sequences, the peptide components [zinc finger protein-/transcription activator-like effector (TALE)-binding domains, FokI variants and linker peptide/framework], the efficiency and specificity of their activities. The database also lists EEN engineering tools and resources as well as information about forms and types of EENs, EEN screening and construction methods, detection methods for targeting efficiency and many other utilities. The aim of EENdb is to represent a central hub for EEN information and an integrated solution for EEN engineering. These studies may help to extract in-depth properties and common rules regarding ZFN or TALEN efficiency through comparison of the known ZFNs or TALENs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.