ReviewInternational journal of molecular sciences2012
A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics.Frontiers in immunology · 2025Review
- Review on role of honey in disease prevention and treatment through modulation of biological activities.Open life sciences · 2025Review
- Fruits, Spices and Honey Phenolic Compounds: A Comprehensive Review on Their Origin, Methods of Extraction and Beneficial Health Properties.Antioxidants (Basel, Switzerland) · 2024Review
- Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins.European journal of nutrition · 2023Article
- In Vitro Antiproliferative Apoptosis Induction and Cell Cycle Arrest Potential of Saudi Sidr Honey against Colorectal Cancer.Nutrients · 2023Article
- A Comprehensive Survey of Phenolic Constituents Reported in Monofloral Honeys around the Globe.Foods (Basel, Switzerland) · 2022Review
- Antimicrobial, immunomodulatory and cytotoxic activities of green synthesized nanoparticles from Acacia honey andSaudi journal of biological sciences · 2021Article
- Multidimensional Comparative Analysis of Bioactive Phenolic Compounds of Honeys of Various Origin.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Fisetin: An anticancer perspective.Food science & nutrition · 2021Review
- Meripilus giganteus ethanolic extract exhibits pro-apoptotic and anti-proliferative effects in leukemic cell lines.BMC complementary and alternative medicine · 2018Article
- Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action.Oxidative medicine and cellular longevity · 2018Review
- Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey.Environmental science and pollution research international · 2017Review
- Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids.Current genomics · 2017Article
- Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits.Oxidative medicine and cellular longevity · 2017Review
- Therapeutic Properties of Bioactive Compounds from Different Honeybee Products.Frontiers in pharmacology · 2017Review
- Effects of honey and its mechanisms of action on the development and progression of cancer.Molecules (Basel, Switzerland) · 2014Review
- Polyphenols as key players for the antileukaemic effects of propolis.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Recent advances in developing insect natural products as potential modern day medicines.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematologic malignancies constitute about 9% of all new cases of cancers as reported via the GLOBOCAN series by International Agency for Research on Cancer (IARC) in 2008. So far, the conventional therapeutic and surgical approaches to cancer therapy have not been able to curtail the rising incidence of cancers, including hematological malignancies, worldwide. The last decade has witnessed great research interest in biological activities of phenolic compounds that include anticancer, anti-oxidation and anti-inflammation, among other things. A large number of anticancer agents combat cancer through cell cycle arrest, induction of apoptosis and differentiation, as well as through inhibition of cell growth and proliferation, or a combination of two or more of these mechanisms. Various phenolic compounds from different sources have been reported to be promising anticancer agents by acting through one of these mechanisms. Honey, which has a long history of human consumption both for medicinal and nutritional uses, contains a variety of phenolic compounds such as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms of the anti-leukemic activity of various phenolic compounds on cell cycle, cell growth and proliferation and apoptosis, and it advocates that more studies should be conducted to determine the potential role of honey in both chemoprevention and chemotherapy in leukemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.