ArticlePediatric research2013
RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children.PloS one · 2016Trial
- Global prevalence of infections in newborns with respiratory complications: systematic review and meta-analysis.Iranian journal of microbiology · 2024Article
- Evaluation of Etiological Causes and Factors Affect Length of Hospitalization in Neonates Hospitalized with Lower Respiratory Tract Infection.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Decreased Passive Immunity to Respiratory Viruses through Human Milk during the COVID-19 Pandemic.Microbiology spectrum · 2022Article
- Effect of Risk-Focused Diversified Safety Management Mode in Patients with Major Artery Stent Implantation.Emergency medicine international · 2022Article
- Impact of respiratory viruses in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Viral Respiratory Infections in the Neonatal Intensive Care Unit-A Review.Frontiers in microbiology · 2018Review
- [Rhinovirus: Underestimated pathogens in patients during the neonatal period].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2017Article
- Parainfluenza 3 Respiratory Infection Associated with Pericardial Effusion in a Very Low Birthweight Infant.Case reports in infectious diseases · 2017Article
- Review of the clinical significance of respiratory virus infections in newborn infants.Acta paediatrica (Oslo, Norway : 1992) · 2016Review
- Defining neonatal sepsis.Current opinion in pediatrics · 2016Review
- Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China.BMC infectious diseases · 2015Article
- Time for a neonatal-specific consensus definition for sepsis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2014Review
- Respiratory viral infections are not uncommon in neonatal intensive care units.Acta paediatrica (Oslo, Norway : 1992) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to determine the prevalence of respiratory pathogens among newborns admitted to a neonatal medium care unit (NMCU) and to identify clinical predictors.
methodsA 1-y observational study was performed of neonates admitted to an NMCU in Amsterdam, The Netherlands. Nasopharyngeal samples were collected for the detection of respiratory viruses and bacteria by real-time PCR (RT-PCR). Cycle threshold (Ct) values were provided to estimate viral load. Predictors for the presence of study pathogens were identified.
resultsFrom October 2010 through September 2011, 334 neonates (median age 1.3 d, 53.6% male) were included. Overall, 37 respiratory pathogens were detected in 34 children (10.2%): parainfluenza-1 (n = 9), human rhinovirus (n = 7), parainfluenza-3 (n = 6), respiratory syncytial virus (RSV, n = 6), Streptococcus pneumoniae (n = 3), adenovirus (n = 2), human coronavirus (n = 2), influenza A (n = 1), and bocavirus (n = 1). Neonates with higher viral loads (Ct <35; n = 11) were more often clinically ill than those with lower viral loads (Ct ≥35; n = 23). Two variables significantly contributed to the detection of study pathogens: age (odds ratio (OR) 1.21 for each day older; 95% confidence interval 1.12-1.30) and rhinorrhea (OR 6.71; 95% confidence interval 1.54-29.21).
conclusionRespiratory pathogens seem to play a role in neonates admitted to an NMCU. The influence of respiratory pathogen detection on clinical management remains to be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.