ArticleViruses2012
miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction.
Article in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- The diverse roles of miRNAs in HIV pathogenesis: Current understanding and future perspectives.Frontiers in immunology · 2022Review
- hsa-miR-191-5p inhibits replication of human immunodeficiency virus type 1 by downregulating the expression of NUP50.Archives of virology · 2021Article
- Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture.Scientific reports · 2017Article
- SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.Scientific reports · 2016Article
- SAMHD1 expression in blood cells of HIV-1 elite suppressors and viraemic progressors.The Journal of antimicrobial chemotherapy · 2015Article
- Interaction of drugs of abuse and microRNA with HIV: a brief review.Frontiers in microbiology · 2015Review
- MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations.Biomarker insights · 2015Review
- miR-190b is markedly upregulated in the intestine in response to simian immunodeficiency virus replication and partly regulates myotubularin-related protein-6 expression.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- OpenArray profiling reveals no differential modulation of miRNA by positive and negative CD4+ T cell immunoselection.Experimental hematology · 2014Article
- miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP.PloS one · 2014Article
- RNA viruses and microRNAs: challenging discoveries for the 21st century.Physiological genomics · 2013Review
- Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system.Molecular brain · 2013Article
- SIV replication is directly downregulated by four antiviral miRNAs.Retrovirology · 2013Article
- Review
- Article
- MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts.BMC infectious diseases · 2013Article
- Data submission and quality in microarray-based microRNA profiling.Clinical chemistry · 2013Review
- HLA-G/C, miRNAs, and their role in HIV infection and replication.BioMed research international · 2013Review
- Comparison of Methods for miRNA Extraction from Plasma and Quantitative Recovery of RNA from Cerebrospinal Fluid.Frontiers in genetics · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Long-lived HIV-1 reservoirs include tissue macrophages. Monocyte-derived macrophages are more susceptible to infection and more permissive to HIV-1 replication than monocytes for reasons that may include the effects of different populations of miRNAs in these two cell classes. Specifically, miRs-28-3p, -150, -223, -198, and -382 exert direct or indirect negative effects on HIV-1 and are reportedly downmodulated during monocyte-to-macrophage differentiation. Here, new experimental results are presented along with reviews and analysis of published studies and publicly available datasets, supporting a broader role of miRNAs in HIV-1 restriction than would be suggested by a simple and uniform downregulation of anti-HIV miRNAs during monocyte-to-macrophage differentiation. Although miR-223 is downregulated in macrophages, other putatively antiviral miRNAs are more abundant in macrophages than in monocytes or are rare and/or variably present in both cell classes. Our analyses point to the need for further studies to determine miRNA profiles of monocytes and macrophages, including classic and newly identified subpopulations; examine the sensitivity of miRNA profiling to cell isolation and differentiation protocols; and characterize rigorously the antiviral effects of previously reported and novel predicted miRNA-HIV-1 interactions in cell-specific contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.