ReviewToxins2012
Advances in deoxynivalenol toxicity mechanisms: the brain as a target.
Review in Toxins, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 107 citations in OpenAlex.
- Interactive effects of the feed-borne mycotoxin deoxynivalenol and a mixed-species Eimeria challenge on layer pullets during the transition to lay.Poultry science · 2026Article
- Article
- Review
- Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses.Environment & health (Washington, D.C.) · 2025Article
- Disorders of Iron Metabolism: A "Sharp Edge" of Deoxynivalenol-Induced Hepatotoxicity.Metabolites · 2025Article
- Bioaerosol Exposures and Respiratory Diseases in Cannabis Workers.Current allergy and asthma reports · 2024Review
- Deoxynivalenol Mycotoxin Inhibits Rabies Virus Replication In Vitro.International journal of molecular sciences · 2023Article
- Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research.Frontiers in microbiology · 2023Review
- Article
- Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol.Journal of neuroinflammation · 2022Article
- Deoxynivalenol Degradation by Various Microbial Communities and Its Impacts on Different Bacterial Flora.Toxins · 2022Article
- Neurotoxic Potential of Deoxynivalenol in Murine Brain Cell Lines and Primary Hippocampal Cultures.Toxins · 2022Article
- The Effects of MixedToxins · 2021Article
- Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.International journal of molecular sciences · 2021Review
- QuEChERS LC-MS/MS Screening Method for Mycotoxin Detection in Cereal Products and Spices.International journal of environmental research and public health · 2021Article
- Baicalin-Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets.Frontiers in nutrition · 2021Article
- The mycotoxin deoxynivalenol activates GABAergic neurons in the reward system and inhibits feeding and maternal behaviours.Archives of toxicology · 2020Article
- The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice.Scientific reports · 2020Article
- Trichothecenes in Cereal Grains - An Update.Toxins · 2019Review
Corrections and comments
- Republished as
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deoxynivalenol (DON), mainly produced by Fusarium fungi, and also commonly called vomitoxin, is a trichothecene mycotoxin. It is one of the most abundant trichothecenes which contaminate cereals consumed by farm animals and humans. The extent of cereal contamination is strongly associated with rainfall and moisture at the time of flowering and with grain storage conditions. DON consumption may result in intoxication, the severity of which is dose-dependent and may lead to different symptoms including anorexia, vomiting, reduced weight gain, neuroendocrine changes, immunological effects, diarrhea, leukocytosis, hemorrhage or circulatory shock. During the last two decades, many studies have described DON toxicity using diverse animal species as a model. While the action of the toxin on peripheral organs and tissues is well documented, data illustrating its effect on the brain are significantly less abundant. Yet, DON is known to affect the central nervous system. Recent studies have provided new evidence and detail regarding the action of the toxin on the brain. The purpose of the present review is to summarize critical studies illustrating this central action of the toxin and to suggest research perspectives in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.