ArticleSensors (Basel, Switzerland)2012
Interface design for CMOS-integrated Electrochemical Impedance Spectroscopy (EIS) biosensors.
Article in Sensors (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Removal of Thiol-SAM on a Gold Surface for Re-Use of an Interdigitated Chain-Shaped Electrode.Materials (Basel, Switzerland) · 2022Article
- Recent advances and challenges in electrochemical biosensors for emerging and re-emerging infectious diseases.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2020Review
- Electrochemical impedimetric biosensors for food safety.Food science and biotechnology · 2020Review
- A 0.18 μm CMOS LDO Regulator for an On-Chip Sensor Array Impedance Measurement System.Sensors (Basel, Switzerland) · 2018Article
- Frequency Response of Graphene Electrolyte-Gated Field-Effect Transistors.Sensors (Basel, Switzerland) · 2018Article
- Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy.Sensors (Basel, Switzerland) · 2016Article
- AC and Phase Sensing of Nanowires for Biosensing.Biosensors · 2016Article
- An Impedance Aptasensor with Microfluidic Chips for Specific Detection of H5N1 Avian Influenza Virus.Sensors (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical Impedance Spectroscopy (EIS) is a powerful electrochemical technique to detect biomolecules. EIS has the potential of carrying out label-free and real-time detection, and in addition, can be easily implemented using electronic integrated circuits (ICs) that are built through standard semiconductor fabrication processes. This paper focuses on the various design and optimization aspects of EIS ICs, particularly the bio-to-semiconductor interface design. We discuss, in detail, considerations such as the choice of the electrode surface in view of IC manufacturing, surface linkers, and development of optimal bio-molecular detection protocols. We also report experimental results, using both macro- and micro-electrodes to demonstrate the design trade-offs and ultimately validate our optimization procedures.
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Registered trials
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