ArticleNature genetics2013
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Registry-linked trialAbstract read
In one paragraph
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05166447 (Twenty-year Follow-up of the Inter99 Cohort), which is not on this map. Cited by 176 papers, 11 of them syntheses that pooled it.
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0cells of the map it votes in
176citing papers in PubMed, 11 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05166447 enrolling by invitationnot on this mapstarted 2021, after this paper: background citation
Twenty-year Follow-up of the Inter99 Cohort
Who cites it
176 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight.Human molecular genetics · 2021Pooled it
- Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy.PLoS genetics · 2020Pooled it
- Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.Nature genetics · 2019Pooled it
- Birth weight and risk of ischemic heart disease: A Mendelian randomization study.Scientific reports · 2016Pooled it
- Pooled it
- Metabolic signatures of birthweight in 18 288 adolescents and adults.International journal of epidemiology · 2016Pooled it
- Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.British journal of cancer · 2016Pooled it
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nature communications · 2016Pooled it
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.PLoS genetics · 2015Pooled it
- Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.Human molecular genetics · 2013Pooled it
- The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.Human molecular genetics · 2013Pooled it
- Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth.Human genetics · 2021Trial
- Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.Scientific reports · 2021Trial
- Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.Human genetics · 2018Trial
- Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways.Diabetologia · 2026Article
- Global burden, projections, and causal factors of maternal sepsis and other maternal infections: A comprehensive epidemiological and mendelian randomization study.PLoS neglected tropical diseases · 2026Article
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
- A bespoke non-invasive approach to predict fetal genotype in pregnancy.Frontiers in medicine · 2026Article
- Genomic approaches to understanding pregnancy phenotypes and birth outcomes and their links with long-term maternal and offspring health-the value of distinguishing maternal and fetal genetic effects.Frontiers in genetics · 2026Review
- The genetics of low and high birthweight and their relationship with cardiometabolic disease.Diabetologia · 2025Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
150 authors.
Momoko HorikoshiOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Hanieh Yaghootkar
Dennis O Mook-Kanamori
Ulla Sovio
H Rob Taal
Branwen J Hennig
Jonathan P Bradfield
Beate St Pourcain
David M Evans
Pimphen Charoen
Marika Kaakinen
Diana L Cousminer
Terho Lehtimäki
Eskil Kreiner-Møller
Nicole M Warrington
Mariona Bustamante
Bjarke Feenstra
Diane J Berry
Elisabeth Thiering
Thiemo Pfab
Sheila J Barton
Beverley M Shields
Marjan Kerkhof
Elisabeth M van Leeuwen
Anthony J Fulford
Zoltán Kutalik
Jing Hua Zhao
Marcel den Hoed
Anubha Mahajan
Virpi Lindi
Liang-Kee Goh
Jouke-Jan Hottenga
Ying Wu
Olli T Raitakari
Marie N Harder
Aline Meirhaeghe
Ioanna Ntalla
Rany M Salem
Karen A Jameson
Kaixin Zhou
Dorota M Monies
Vasiliki Lagou
Mirna Kirin
Jani Heikkinen
Linda S Adair
Fowzan S Alkuraya
Ali Al-Odaib
Philippe Amouyel
Ehm Astrid Andersson
Amanda J Bennett
Alexandra I F Blakemore
Jessica L Buxton
Jean Dallongeville
Shikta Das
Eco J C de Geus
Xavier Estivill
Claudia Flexeder
Philippe Froguel
Frank Geller
Keith M Godfrey
Frédéric Gottrand
Christopher J Groves
Torben Hansen
Joel N Hirschhorn
Albert Hofman
Mads V Hollegaard
David M Hougaard
Elina Hyppönen
Hazel M Inskip
Aaron Isaacs
Torben Jørgensen
Christina Kanaka-Gantenbein
John P Kemp
Wieland Kiess
Tuomas O Kilpeläinen
Norman Klopp
Bridget A Knight
Christopher W Kuzawa
George McMahon
John P Newnham
Harri Niinikoski
Ben A Oostra
Louise Pedersen
Dirkje S Postma
Susan M Ring
Fernando Rivadeneira
Neil R Robertson
Sylvain Sebert
Olli Simell
Torsten Slowinski
Carla M T Tiesler
Anke Tönjes
Allan Vaag
Jorma S Viikari
Jacqueline M Vink
Nadja Hawwa Vissing
Nicholas J Wareham
Gonneke Willemsen
Daniel R Witte
Haitao Zhang
Jianhua Zhao
Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC)
James F Wilson
Michael Stumvoll
Andrew M Prentice
Brian F Meyer
Ewan R Pearson
Colin A G Boreham
Cyrus Cooper
Matthew W Gillman
George V Dedoussis
Luis A Moreno
Oluf Pedersen
Maiju Saarinen
Karen L Mohlke
Dorret I Boomsma
Seang-Mei Saw
Timo A Lakka
Antje Körner
Ruth J F Loos
Ken K Ong
Peter Vollenweider
Cornelia M van Duijn
Gerard H Koppelman
Andrew T Hattersley
John W Holloway
Berthold Hocher
Joachim Heinrich
Chris Power
Mads Melbye
Mònica Guxens
Craig E Pennell
Klaus Bønnelykke
Hans Bisgaard
Johan G Eriksson
Elisabeth Widén
Hakon Hakonarson
André G Uitterlinden
Anneli Pouta
Debbie A Lawlor
George Davey Smith
Timothy M Frayling
Mark I McCarthy
Struan F A Grant
Vincent W V Jaddoe
Marjo-Riitta Jarvelin
Nicholas J Timpson
Inga Prokopenko
Rachel M Freathy
Early Growth Genetics (EGG) Consortium
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MCarolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0MGenome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5MGenome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6MGenetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MGenetic Influences on ADHD in a Finnish Birth CohortR01MH063706 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALLEY, SUSAN L · 2001 to 2005
$3.3MGenetic Epidemiology of Body Mass Index, Adiposity and Weight GainR01DK078150 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2007 to 2010
$2.3MArthritis Research UK 13085Arthritis Research UK 13147Arthritis Research UK 13157Arthritis Research UK 13181Arthritis Research UK 13230Arthritis Research UK 16095Arthritis Research UK 16349Arthritis Research UK 17265Arthritis Research UK 17413Arthritis Research UK 17702British Heart Foundation RG/07/009/23120Cancer Research UKChief Scientist Office CZB/4/710CIHR MOP-82893European Research Council 230374FIC NIH HHS R01 TW005596FIC NIH HHS TW05596Medical Research Council G0400491Medical Research Council G0600331Medical Research Council G0600705Medical Research Council G0601261Medical Research Council G0601653Medical Research Council G1002084Medical Research Council G9815508Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U106188470Medical Research Council MC_U123292700Medical Research Council MC_U123292701Medical Research Council MC_U147574215Medical Research Council MC_U147574217Medical Research Council MC_U147574221Medical Research Council MC_U147574233Medical Research Council MC_U147574236Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council U.1475.00.002.00001.01(74218)Medical Research Council U.1475.00.003.00010.02(74237)Medical Research Council U.1475.00.003.00010.02(74238)Medical Research Council U.1475.00.003.00010.02(74242)NCHHSTP CDC HHS U22 PS000476NCRR NIH HHS P20 RR020649NCRR NIH HHS RR20649NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01HG004423NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01HG004446NHLBI NIH HHS 5R01HL087679-02NHLBI NIH HHS HL085144NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL087679NICHD NIH HHS 1R01HD056465-01ANICHD NIH HHS HD054501NICHD NIH HHS R01 HD054501NICHD NIH HHS R01 HD056465NICHD NIH HHS R24 HD050924NIDDK NIH HHS DK078150NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01DK075787NIDDK NIH HHS R01 DK078150NIDDK NIH HHS U01 DK062418NIDDK NIH HHS U01DK062418NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126NIMH NIH HHS 1RL1MH083268-01NIMH NIH HHS 5R01MH63706:02NIMH NIH HHS MH081802NIMH NIH HHS R01 MH063706NIMH NIH HHS R01 MH081802NIMH NIH HHS RL1 MH083268NIMH NIH HHS U24 MH068457NIMH NIH HHS U24 MH068457-06PHS HHS R01D0042157-01AWellcome Trust 068545/Z/02Wellcome Trust 076467Wellcome Trust 083270Wellcome Trust 083948Wellcome Trust 085301Wellcome Trust 085541Wellcome Trust 085541/Z/08/ZWellcome Trust 090532Wellcome Trust 092731Wellcome Trust GR069224Wellcome Trust WT083431MAWellcome Trust WT088806Wellcome Trust WT089549
Abstract
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Indexed as
Genetic LinkageQuantitative Trait LociAdultBirth WeightBlood PressureBody HeightDiabetes Mellitus, Type 2FemaleFetal DevelopmentGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInfant, NewbornMaleMeta-Analysis as TopicPolymorphism, Single Nucleotide
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NCT05166447ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.