ArticleHuman molecular genetics2013
FTO, obesity and the adolescent brain.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity.BMC medical genetics · 2018Trial
- Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort.Human brain mapping · 2026Article
- Cardiometabolic risk and structural brain development in a large community-based U.S. cohort.medRxiv : the preprint server for health sciences · 2025Article
- FTO variation and early frontostriatal brain development in children.Obesity (Silver Spring, Md.) · 2024Article
- Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain.International journal of molecular sciences · 2022Review
- The epitranscriptome and synaptic plasticity.Current opinion in neurobiology · 2019Review
- Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.Scientific reports · 2019Observational
- The role of mRNA mCell & bioscience · 2019Review
- Epitranscriptomic Code and Its Alterations in Human Disease.Trends in molecular medicine · 2018Review
- Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders.Frontiers in bioengineering and biotechnology · 2018Review
- Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.Human molecular genetics · 2017Article
- Cohort Profile: The Saguenay Youth Study (SYS).International journal of epidemiology · 2017Article
- Multiple regression analysis of the craniofacial region of Chinese Han people using linear and angular measurements based on MRI.Forensic sciences research · 2017Article
- A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.Journal of human genetics · 2016Article
- Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes and Lower Levels of Positive Emotionality.Frontiers in neuroscience · 2016Article
- Development and aging of cortical thickness correspond to genetic organization patterns.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Multi-level block permutation.NeuroImage · 2015Article
- Does the brain shrink as the waist expands?Ageing research reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 18 institutions in 5 countries.
Funding
Abstract
Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO. We studied a population-based sample of 598 adolescents recruited from the French Canadian founder population in whom we measured brain volume by magnetic resonance imaging. Total fat mass was assessed with bioimpedance and body mass index was determined with anthropometry. Genotype-phenotype associations were tested with Merlin under an additive model. We found that the G allele of FTO (rs9930333) was associated with higher total body fat [TBF (P = 0.002) and lower brain volume (P = 0.005)]. The same allele was also associated with higher lean body mass (P = 0.03) and no difference in height (P = 0.99). Principal component analysis identified a shared inverse variance between the brain volume and TBF, which was associated with FTO at P = 5.5 × 10(-6). These results were replicated in two independent samples of 413 and 718 adolescents, and in a meta-analysis of all three samples (n = 1729 adolescents), FTO was associated with this shared inverse variance at P = 1.3 × 10(-9). Co-expression networks analysis supported the possibility that the underlying FTO effects may occur during embryogenesis. In conclusion, FTO is associated with shared inverse variance between body adiposity and brain volume, suggesting that this gene may exert inverse effects on adipose and brain tissues. Given the completion of the overall brain growth in early childhood, these effects may have their origins during early development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.