Trial reportGynecologic oncology2013
Is bilateral lymphadenectomy for midline squamous carcinoma of the vulva always necessary? An analysis from Gynecologic Oncology Group (GOG) 173.
Trial report in Gynecologic oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Detection of sentinel lymph node in vulvar cancer usingArchives of gynecology and obstetrics · 2023Pooled it
- Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of vulvar cancer and vaginal cancer.International journal of clinical oncology · 2018Guideline
- Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer.The Cochrane database of systematic reviews · 2014Pooled it
- Cancer of the vulva: 2025 update: FIGO Cancer Report 2025.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Effect of known pathological risk factors on the incidence of metastatic lymph nodes and survival in early-stage vulvar cancer: SEER analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2024Article
- Endometrial cancer intraoperative sentinel lymph node identification can effectively guide treatment.American journal of translational research · 2023Article
- Management of Early-Stage Vulvar Cancer.Cancers · 2022Review
- Review
- Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: a proposed protocol for a multicentre observational study.BMC cancer · 2022Article
- The giant steps in surgical downsizing toward a personalized treatment of vulvar cancer.The journal of obstetrics and gynaecology research · 2022Review
- Cancer of the vulva: 2021 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021Article
- Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.American journal of clinical dermatology · 2021Review
- PROGNOSTIC FACTORS FOR VULVAR CANCER.Acta clinica Croatica · 2021Article
- Status of Sentinel Lymph Node Biopsy in Vulvar and Cervical Cancer.Geburtshilfe und Frauenheilkunde · 2020Article
- Lymphoscintigraphy and sentinel lymph node biopsy in vulvar carcinoma: update from a European expert panel.European journal of nuclear medicine and molecular imaging · 2020Review
- The use of SPECT/CT for anatomical mapping of lymphatic drainage in vulvar cancer: possible implications for the extent of inguinal lymph node dissection.European journal of nuclear medicine and molecular imaging · 2015Article
- Vulvar cancer: epidemiology, clinical presentation, and management options.International journal of women's health · 2015Review
- Therapy for Primary Vulvar Carcinoma.Geburtshilfe und Frauenheilkunde · 2014Article
- A Nomogram for Predicting Cancer-Specific Survival in Patients With Stage I Vulvar Squamous Cell Carcinoma: A Study Based on the SEER Database and External Validation.Cancer control : journal of the Moffitt Cancer CenterArticle
- Comprehensive management of vulvovaginal cancers.CA: a cancer journal for cliniciansReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 16 institutions in 1 country.
Funding
Abstract
objectiveTo determine which patients with near midline lesions may safely undergo unilateral groin dissection based on clinical exam and lymphoscintigraphy (LSG) results.
methodsPatients participating in GOG-173 underwent sentinel lymph node (SLN) localization with blue dye, and radiocolloid with optional LSG before definitive inguinal-femoral lymphadenectomy (LND). This analysis interrogates the reliability of LSG alone relative to primary tumor location in those patients who had an interpretable LSG and at least one SLN identified. Primary tumor location was categorized as lateral (>2cm from midline), midline, or lateral ambiguous (LA) if located within 2cm, but not involving the midline.
resultsTwo-hundred-thirty-four patients met eligibility criteria. Sixty-four had lateral lesions, and underwent unilateral LND. All patients with LA (N=65) and midline (N=105) tumors underwent bilateral LND. Bilateral drainage by LSG was identified in 14/64 (22%) patients with lateral tumors, 38/65 (58%) with LA tumors and in 73/105 (70%) with midline tumors. At mapping, no SLNs were found in contralateral groins among those patients with LA and midline tumors who had unilateral-only LSGs. However, in these patients groin metastases were found in 4/32 patients with midline tumors undergoing contralateral dissection; none were found in 27 patients with LA tumors.
conclusionThe likelihood of detectable bilateral drainage using preoperative LSG decreases as a function of distance from midline. Patients with LA primaries and unilateral drainage on LSG may safely undergo unilateral SLN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.