ArticleDevelopmental biology2013
Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 55 citations in OpenAlex.
- Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions.Communications biology · 2025Article
- Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis.Disease models & mechanisms · 2024Article
- Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Review
- Article
- Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.Disease models & mechanisms · 2022Article
- DNA-based eyelid trait prediction in Chinese Han population.International journal of legal medicine · 2021Article
- Creating Avian Forebrain Chimeras to assess Facial Development.Journal of visualized experiments : JoVE · 2021Article
- Programmed Cell Death Not as Sledgehammer but as Chisel: Apoptosis in Normal and Abnormal Craniofacial Patterning and Development.Frontiers in cell and developmental biology · 2021Review
- FGF signaling regulates development by processes beyond canonical pathways.Genes & development · 2020Article
- Article
- Comparative growth in the olfactory system of the developing chick with considerations for evolutionary studies.Journal of anatomy · 2020Article
- Evolvability of the vertebrate craniofacial skeleton.Seminars in cell & developmental biology · 2019Review
- A tale of two cities: The genetic mechanisms governing calvarial bone development.Genesis (New York, N.Y. : 2000) · 2019Review
- Sculpting the skull through neurosensory epithelial-mesenchymal signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- MAPK and PI3K signaling: At the crossroads of neural crest development.Developmental biology · 2018Review
- Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.eLife · 2018Article
- Developmental nonlinearity drives phenotypic robustness.Nature communications · 2017Article
- Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.Human molecular genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Craniofacial development requires an exquisitely timed and positioned cross-talk between the embryonic cephalic epithelia and mesenchyme. This cross-talk underlies the precise translation of patterning processes and information into distinct, appropriate skeletal morphologies. The molecular and cellular dialogue includes communication via secreted signaling molecules, including Fgf8, and effectors of their interpretation. Herein, we use genetic attenuation of Fgf8 in mice and perform gain-of-function mouse-chick chimeric experiments to demonstrate that significant character states of the frontonasal and optic skeletons are dependent on Fgf8. Notably, we show that the normal orientation and polarity of the nasal capsules and their developing primordia are dependent on Fgf8. We further demonstrate that Fgf8 is required for midfacial integration, and provide evidence for a role for Fgf8 in optic capsular development. Taken together, our data highlight Fgf8 signaling in craniofacial development as a plausible target for evolutionary selective pressures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.