ArticleVision research2013
Normal binocular rivalry in autism: implications for the excitation/inhibition imbalance hypothesis.
Article in Vision research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 72 citations in OpenAlex.
- Age-dependency in binocular rivalry is reflected by exclusive percepts, not mixed percepts.Scientific reports · 2019Trial
- GABAergic Inhibition Gates Perceptual Awareness During Binocular Rivalry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Differential effects of attention and contrast on transition appearance during binocular rivalry.Journal of vision · 2026Article
- Differential effects of left DLPFC anodal and cathodal tDCS interventions on the brain in children with autism: A randomized controlled trial.IBRO neuroscience reports · 2025Article
- The complexity of human subjective experience during binocular rivalry.Neuroscience of consciousness · 2025Article
- Autism spectrum disorder variation as a computational trade-off via dynamic range of neuronal population responses.Nature neuroscience · 2024Article
- Article
- Dopamine Dysregulation in Reward and Autism Spectrum Disorder.Brain sciences · 2024Review
- The direction of theta and alpha travelling waves modulates human memory processing.Nature human behaviour · 2024Article
- Reduced processing of afforded actions while observing mental content as ongoing mental phenomena.Scientific reports · 2024Article
- Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Review
- Event-Related Desynchronization of MEG Alpha-Band Oscillations during Simultaneous Presentation of Audio and Visual Stimuli in Children with Autism Spectrum Disorder.Brain sciences · 2023Article
- Binocular rivalry in autistic and socially anxious adults.Frontiers in psychiatry · 2023Article
- Visual consciousness dynamics in adults with and without autism.Scientific reports · 2022Article
- Perceptual Grouping During Binocular Rivalry in Mild Glaucoma.Frontiers in aging neuroscience · 2022Article
- Priming and reversals of the perceived ambiguous orientation of a structure-from-motion shape and relation to personality traits.PloS one · 2022Article
- Interictal Activity Is Associated With Slower Binocular Rivalry in Idiopathic Generalized Epilepsy.Frontiers in neurology · 2021Article
- Using psychophysical performance to predict short-term ocular dominance plasticity in human adults.Journal of vision · 2020Article
- Frequency of alpha oscillation predicts individual differences in perceptual stability during binocular rivalry.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Autism is characterized by disruption in multiple dimensions of perception, emotion, language and social cognition. Many hypotheses for the underlying neurophysiological basis have been proposed. Among these is the excitation/inhibition (E/I) imbalance hypothesis, which states that levels of cortical excitation and inhibition are disrupted in autism. We tested this theory in the visual system, because vision is one of the better understood systems in neuroscience, and because the E/I imbalance theory has been proposed to explain hypersensitivity to sensory stimuli in autism. We conducted two experiments on binocular rivalry, a well-studied psychophysical phenomenon that depends critically on excitation and inhibition levels in cortex. Using a computational model, we made specific predictions about how imbalances in excitation and inhibition levels would affect perception during two aspects of binocular rivalry: mixed perception (Experiment 1) and traveling waves (Experiment 2). We found no significant differences in either of these phenomena between high-functioning adults with autism and controls, and no evidence for a relationship between these measurements and the severity of autism. These results do not conclusively rule out an excitation/inhibition imbalance in the visual system of those with autism, but they suggest that such an imbalance, if it exists, is likely to be small in magnitude.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.