Evidence map›Paper›PMID 23200845›Full record

ArticleArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2013

Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study.

Patrick Vavken, Benedikt Proffen, Chris Peterson, Braden C Fleming, Jason T Machan, Martha M Murray

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Optimizing outcomes of ACL surgery-Is autograft reconstruction the only reasonable option?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Review
  5. Article
  6. Review
  7. Paediatric proximal ACL tears managed with direct ACL repair is safe, effective and has excellent short-term outcomes.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020
    Article
  8. Article
  9. Article
  10. Anterior cruciate ligament repair - past, present and future.Journal of experimental orthopaedics · 2018
    Review
  11. Magnetic resonance measurements of tissue quantity and quality using TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018
    Article
  12. Article
  13. Article
  14. Article
  15. Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patrick VavkenSports Medicine Research Laboratory, Department of Orthopedic Surgery, Children's Hospital Boston, Harvard Medical School, Massachusetts, USA. patrick.vavken@childrens.harvard.edu
Benedikt Proffen
Chris Peterson
Braden C Fleming
Jason T Machan
Martha M Murray

Funding

Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
The Effect of Age on Functional ACL HealingR01AR054099 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI MURRAY, MARTHA M · 2006 to 2013
$4.8M
A Novel Mechanism for Intra-articular NonunionR01AR052772 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI MURRAY, MARTHA M · 2007 to 2010
$1.4M
NIAMS NIH HHS R01 AR052772NIAMS NIH HHS R01-AR052772NIAMS NIH HHS R01 AR054099NIAMS NIH HHS R01-AR054099NIAMS NIH HHS R01 AR056834NIAMS NIH HHS R01-AR056834
6 · The paper itself

Abstract

purposeThe objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes.

methodsSixteen female skeletally immature Yorkshire pigs were randomly allocated to receive unilateral, bioenhanced ACL repair with an absorbable (Vicryl) or nonabsorbable (Ethibond) suture augmented by an extracellular matrix-based scaffold (MIACH). After 15 weeks of healing, micro-computed tomography was used to measure residual tunnel diameters and growth plate status, and biomechanical outcomes were assessed.

resultsAt 15 weeks postoperatively, there was a significant difference in tunnel diameter with significantly larger diameters in the nonabsorbable suture group (4.4 ± 0.3 mm; mean ± SD) than in the absorbable group (1.8 ± 0.5 mm; P < .001). The growth plate showed a significantly greater affected area in the nonabsorbable group (15.2 ± 3.4 mm(2)) than in the absorbable group (2.7 ± 0.8 mm(2), P < .001). There was no significant difference in the linear stiffness of the repairs (29.0 ± 14.8 N/mm for absorbable v 43.3 ± 28.3 N/mm for nonabsorbable sutures, P = .531), but load to failure was higher in the nonabsorbable suture group (211 ± 121.5 N) than in the absorbable suture group (173 ± 101.4 N, P = .002). There was no difference between the 2 groups in anteroposterior laxity at 30° (P = .5117), 60° (P = .3150), and 90° (P = .4297) of knee flexion.

conclusionsThe use of absorbable sutures for ACL repair resulted in decreased physeal plate damage after 15 weeks of healing; however, use of nonabsorbable sutures resulted in 20% stronger repairs. CLINICAL RELEVANCE: Choice of suture type for ACL repair or repair of tibial avulsion fractures may depend on patient skeletal age and size, with absorbable sutures preferred in very young, small patients at higher risk with physeal damage and nonabsorbable sutures preferred in larger, prepubescent patients who may place higher loads on the repair.

Indexed as

Polyethylene TerephthalatesPolyglactin 910SuturesTissue ScaffoldsWound HealingAbsorbable ImplantsAge FactorsAnimalsAnterior Cruciate Ligament ReconstructionBiomechanical PhenomenaBloodBone DensityCollagenEquipment FailureFemaleFemurCollagenEthibondPolyethylene TerephthalatesPolyglactin 910

Identifiers

PMID23200845
PMCPMC3644616

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.