ArticlePhysiology & behavior2013
Post-oral glucose stimulation of intake and conditioned flavor preference in C57BL/6J mice: a concentration-response study.
Article in Physiology & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- Immediate glucose signaling transmitted via the vagus nerve in gut-brain neural communication.iScience · 2025Article
- Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences.Physiology & behavior · 2024Article
- Mice Condition Cephalic-Phase Insulin Release to Flavors Associated with Postoral Actions of Concentrated Glucose.Nutrients · 2024Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.bioRxiv : the preprint server for biology · 2023Article
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Nutrient-conditioned intake stimulation does not require a distinctive flavor cue in rats.Appetite · 2020Article
- Effects of different sweeteners on behavior and neurotransmitters release in mice.Journal of food science and technology · 2020Article
- Commentary: Sugar Metabolism Regulates Flavor Preferences and Portal Glucose Sensing.Frontiers in integrative neuroscience · 2019Article
- From appetite setpoint to appetition: 50years of ingestive behavior research.Physiology & behavior · 2018Review
- Rewarding Effects of Operant Dry-Licking Behavior on Neuronal Firing in the Nucleus Accumbens Core.Frontiers in pharmacology · 2017Article
- MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice.Physiology & behavior · 2016Article
- Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior.Current opinion in behavioral sciences · 2016Article
- SGLT1 sugar transporter/sensor is required for post-oral glucose appetition.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Operant licking for intragastric sugar infusions: Differential reinforcing actions of glucose, sucrose and fructose in mice.Physiology & behavior · 2016Article
- Dopamine D1 and opioid receptor antagonists differentially reduce the acquisition and expression of fructose-conditioned flavor preferences in BALB/c and SWR mice.Physiology & behavior · 2015Article
- Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice.Physiology & behavior · 2015Article
- Intragastric fat self-administration is impaired in GPR40/120 double knockout mice.Physiology & behavior · 2015Article
- Postoral glucose sensing, not caloric content, determines sugar reward in C57BL/6J mice.Chemical senses · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In a recent study, intragastric (IG) self-infusion of 16% glucose stimulated 1-h intake and conditioned a preference for a flavored saccharin solution in C57BL/6J mice (Zukerman et al., 2011). Experiment 1 of the present study presents a concentration-response analysis of IG glucose-induced intake stimulation monitored by recording licking response every min of the 1h/day sessions. Separate groups of food-restricted mice consumed a flavored saccharin solution (the CS-) paired with IG self-infusions of water (Test 0) followed by a different flavored solution (the CS+) paired with IG self-infusions of 2, 4, 8, 16, or 32% glucose (Tests 1-3). Following additional CS- and CS+ training sessions, a two-bottle CS+ vs. CS- choice test was conducted without infusions. Self-infusions of 8%, 16% or 32% glucose stimulated CS+ licking within 12 min of the first test session and even earlier in subsequent test sessions, and also conditioned significant CS+ preferences in the two-bottle test. The stimulation of early licking and CS+ preference increased as a function of glucose concentration. The amount of glucose solute self-infused increased with sugar concentration as did post-infusion blood glucose levels. The 2% glucose infusion did not stimulate CS+ intake and the 2% and 4% infusions failed to produce a CS+ preference in the 1-h test. Experiment 2 revealed that intraperitoneal self-infusions of 8% glucose, unlike IG glucose self-infusions, failed to stimulate CS+ licking or preference despite producing maximal increases in blood glucose levels. Taken together, these and other findings suggest that glucose rapidly produces concentration-dependent intestinal signals that stimulate intake and condition flavor preferences while post-oral satiation signals limit total amounts consumed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.