ArticleJournal of studies on alcohol and drugs2013
Behavioral control in alcohol use disorders: relationships with severity.
Article in Journal of studies on alcohol and drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03842670 (Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis.BMC psychiatry · 2021Pooled it
- A Randomized Trial of Combined tDCS Over Right Inferior Frontal Cortex and Cognitive Bias Modification: Null Effects on Drinking and Alcohol Approach Bias.Alcoholism, clinical and experimental research · 2019Trial
- Mindfulness-Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double-Blind Sham-Controlled Randomized Trial.Alcoholism, clinical and experimental research · 2019Trial
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.Psychopharmacology · 2015Trial
- Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect.Addiction neuroscience · 2025Article
- Dissociation of self and mother-related processing in abstinent heroin misusers.Translational psychiatry · 2025Article
- Impaired Interference Control in Individuals With Internet Addiction: Evidence From Event-Related Potentials and Brain Oscillations.Addiction biology · 2025Article
- Inhibitory control is affected by reward in patients with alcohol use disorder.Frontiers in psychiatry · 2025Article
- Family history of substance use disorder and parental impulsivity are differentially associated with neural responses during risky decision-making.Frontiers in neuroimaging · 2023Article
- Modeling Aversion Resistant Alcohol Intake in Indiana Alcohol-Preferring (P) Rats.Brain sciences · 2022Article
- Statistical Nonparametric fMRI Maps in the Analysis of Response Inhibition in Abstinent Individuals with History of Alcohol Use Disorder.Behavioral sciences (Basel, Switzerland) · 2022Article
- Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking.Drug and alcohol dependence · 2022Article
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Alcohol Use Disorder and Cannabis Use Disorder Symptomatology in Adolescents and Aggression: Associations With Recruitment of Neural Regions Implicated in Retaliation.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking.International journal of molecular sciences · 2021Review
- Reduced motor cortex GABAMolecular psychiatry · 2021Article
- Stop What You're Doing!-An fMRI Study on Comparisons of Neural Subprocesses of Response Inhibition in ADHD and Alcohol Use Disorder.Frontiers in psychiatry · 2021Article
- Cognitive Modeling Informs Interpretation of Go/No-Go Task-Related Neural Activations and Their Links to Externalizing Psychopathology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Stroop-related cerebellar and temporal activation is correlated with negative affect and alcohol use disorder severity.Brain imaging and behavior · 2020Article
- Altered neural dynamics in occipital cortices serving visual-spatial processing in heavy alcohol users.Journal of psychopharmacology (Oxford, England) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe current study examined the relationship between severity of alcohol use disorders (AUDs) and the neural circuits that underlie response inhibition and error monitoring. In addition, we explored pre- and post-inhibition trial processes to determine the potential causal mechanisms responsible for disinhibition in AUDs.
methodOne hundred sixty-four individuals with a range of drinking from non-treatment-seeking adults with problematic alcohol use to treatment-seeking adults with alcohol dependence completed a Go/NoGo task while undergoing functional magnetic resonance imaging.
resultsCorrelations between signal change during response inhibition and a composite measure of AUD severity revealed significant negative relationships in right insula/inferior frontal gyrus, pregenual anterior cingulate cortex, and inferior parietal lobe. Relationships with error monitoring-related response largely overlapped with that of correct inhibitions but also included rostral anterior cingulate cortex and left inferior frontal gyrus, such that more severe AUDs were associated with reduced response in these regions. Last, examination of pre- and postinhibition processes suggested that more severe AUDs are associated with greater engagement of motor response circuits before inhibition trials, suggesting greater pre-potent tendencies that may lead to disinhibition.
conclusionsThe current results extend previous work by examining how variation in AUD severity is related to neural response during response inhibition and potential causal mechanisms responsible for impaired inhibitory control. More severe AUDs were associated with reduced engagement of neural circuits involved in behavioral control and enhanced pre-potent responding. This altered control may contribute to the progression of AUDs, as well as relapse after treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.