ArticleGenomics, proteomics & bioinformatics2012
miRT: a database of validated transcription start sites of human microRNAs.
Article in Genomics, proteomics & bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets.Functional & integrative genomics · 2023Review
- Diabetes and Colorectal Cancer Risk: Clinical and Therapeutic Implications.Journal of diabetes research · 2022Review
- Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia.Physiological research · 2021Review
- Computational annotation of miRNA transcription start sites.Briefings in bioinformatics · 2021Review
- Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke.Frontiers in genetics · 2019Article
- mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines.Nucleic acids research · 2018Article
- Methods of MicroRNA Promoter Prediction and Transcription Factor Mediated Regulatory Network.BioMed research international · 2017Review
- Infinity: An In-Silico Tool for Genome-Wide Prediction of Specific DNA Matrices in miRNA Genomic Loci.PloS one · 2016Article
- Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.Cardiovascular research · 2015Article
- Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.Pituitary · 2015Article
- Pathogenesis of Systemic Sclerosis.Frontiers in immunology · 2015Review
- Paired-end analysis of transcription start sites in Arabidopsis reveals plant-specific promoter signatures.The Plant cell · 2014Article
- Analysis of microRNA-target interactions across diverse cancer types.Nature structural & molecular biology · 2013Article
- DNA methylation patterns facilitate the identification of microRNA transcription start sites: a brain-specific study.PloS one · 2013Article
- MicroRNAs: mechanisms, functions and progress.Genomics, proteomics & bioinformatics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small endogenous non-coding RNAs of about 22 nt in length that take crucial roles in many biological processes. These short RNAs regulate the expression of mRNAs by binding to their 3'-UTRs or by translational repression. Many of the current studies focus on how mature miRNAs regulate mRNAs, however, very limited knowledge is available regarding their transcriptional loci. It is known that primary miRNAs (pri-miRs) are first transcribed from the DNA, followed by the formation of precursor miRNAs (pre-miRs) by endonuclease activity, which finally produces the mature miRNAs. Till date, many of the pre-miRs and mature miRNAs have been experimentally verified. But unfortunately, identification of the loci of pri-miRs, promoters and associated transcription start sites (TSSs) are still in progress. TSSs of only about 40% of the known mature miRNAs in human have been reported. This information, albeit limited, may be useful for further study of the regulation of miRNAs. In this paper, we provide a novel database of validated miRNA TSSs, miRT, by collecting data from several experimental studies that validate miRNA TSSs and are available for full download. We present miRT as a web server and it is also possible to convert the TSS loci between different genome built. miRT might be a valuable resource for advanced research on miRNA regulation, which is freely accessible at: http://www.isical.ac.in/~bioinfo_miu/miRT/miRT.php.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.