Evidence map›Paper›PMID 23200134›Full record

ReviewGenomics, proteomics & bioinformatics2012

MicroRNAs in common human diseases.

Yu Li, Kris V Kowdley

Abstract readReview
In one paragraph

Review in Genomics, proteomics & bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Altered Expression of CirculatingInternational journal of fertility & sterility · 2024
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yu LiBenaroya Research Institute and Center for Liver Disease, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98101, USA. yli@benaroyaresearch.org
Kris V Kowdley

Funding

Multicentered Randomized Trial of High-dose Urso in PSCR01DK056924 · NIDDK · MAYO CLINIC ROCHESTER · PI TALWALKAR, JAYANT A · 2001 to 2011
$6.5M
THE ROLE OF IRON AND HFE GENOTYPE IN LIVER DISEASEK24DK002957 · NIDDK · UNIVERSITY OF WASHINGTON · PI KOWDLEY, KRIS · 2001 to 2010
$1.5M
Serum Biomarkers Associated With Phenotypic Expression of Hemochromatosis.R21HL112678 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI KOWDLEY, KRIS · 2012 to 2013
$250k
NHLBI NIH HHS 1R21HL112678NHLBI NIH HHS R21 HL112678NIDDK NIH HHS 3R01DK056924-08S1NIDDK NIH HHS 5K24DK002957NIDDK NIH HHS K24 DK002957NIDDK NIH HHS R01 DK056924
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that have attracted tremendous attention from the biological and biomedical research communities over the past decade. With over 1900 miRNAs discovered in humans to date, many of them have already been implicated in common human disorders. Facilitated by high-throughput genomics and bioinformatics in conjunction with traditional molecular biology techniques and animal models, miRNA research is now positioned to make the transition from laboratories to clinics to deliver profound benefits to public health. Herein, we overview the progress of miRNA research related to human diseases, as well as the potential for miRNA to becoming the next generation of diagnostics and therapeutics.

Indexed as

AnimalsComputational BiologyHumansImmune System DiseasesMicroRNAsNeoplasmsNeurodegenerative DiseasesVirus DiseasesMicroRNAs

Identifiers

PMID23200134
PMCPMC3611977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.